RT Journal Article
SR Electronic
T1 P046 Occupational exposures and gastric cancer risk in the MCC-spain case-control study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP A136
OP A136
DO 10.1136/oemed-2016-103951.370
VO 73
IS Suppl 1
A1 Miguel Santibañez
A1 Miguel Ángel Alba
A1 Juan Alguacil
A1 Esther Gracia
A1 Laura Costas
A1 Jose Antonio Garrido
A1 Nuria Aragonés
A1 Beatriz Pérez-Gómez
A1 Antonio José Molina
A1 Tania Fernández
A1 Javier Llorca
A1 Victor Moreno
A1 Jone M Altzibar
A1 Eva Ardanaz
A1 Silvia de Sanjosé
A1 José Juan Jiménez-Moleón
A1 Adonina Tardón
A1 Rocío Capelo
A1 Rosana Peiró
A1 Rafael Marcos-Gragera
A1 Carmen Navarro
A1 Gemma Castaño
A1 Marina Pollán
A1 Ana Maria García
A1 Manolis Kogevinas
YR 2016
UL http://oem.bmj.com/content/73/Suppl_1/A136.1.abstract
AB Objective To explore the relationship between gastric cancer (GC) and occupational exposures.Methods A total of 382 incident GC cases and 2,846 randomly selected population controls with occupational information were included from the MCC-Spain study, a population-based multicase-control study. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the MatEmEsp Job Exposure Matrix. ORs and their 95% confidence intervals (CI) were estimated by unconditional logistic regression adjusting for matching variables and education.Results In men, a statistically significant increased risk of GC, was found for ‘Employed skilled workers in agricultural activities’ (OR 4.4) and a borderline association was found for ‘miners and quarry workers’ (OR 1.8, 95% CI: 0.9 to 3.4). Regarding occupational exposures, a statistically significant association was found for long term exposure (>10 years) to ‘insecticides’ in women (OR 2.68) and a borderline association was found in men (OR 1.43, 95% CI: 0.94 to 2.17). In men, a statistically significant increased risk of GC for the highest level of exposure to ‘ioninzing radiation’ (2.08), and ‘silica dust’ (OR1.52) was also found. In women, statistically significant associations were found for the highest level of exposure to some dusty exposures such as ‘flour dust’ (OR 1.76), or ‘other mineral dust different from silica’ (OR 2.07). A borderline association was found in women for other dusty exposures such as ‘paper pulp&dust’ (OR 3.22, 95% CI: 0.99 to 10.45), and non-significant increases of risk were found for ‘leather dust’ (OR 2.30, 95% CI: 0.58 to 9.17) and ‘textile dust’ (OR 2.30, 95% CI: 0.59 to 9.92).Conclusions This study supports the relationship previously suggested between GC and ionising radiation, pesticides or occupational exposure to dusty environments.