@article {Santiba{\~n}ezA136, author = {Miguel Santiba{\~n}ez and Miguel {\'A}ngel Alba and Juan Alguacil and Esther Gracia and Laura Costas and Jose Antonio Garrido and Nuria Aragon{\'e}s and Beatriz P{\'e}rez-G{\'o}mez and Antonio Jos{\'e} Molina and Tania Fern{\'a}ndez and Javier Llorca and Victor Moreno and Jone M Altzibar and Eva Ardanaz and Silvia de Sanjos{\'e} and Jos{\'e} Juan Jim{\'e}nez-Mole{\'o}n and Adonina Tard{\'o}n and Roc{\'\i}o Capelo and Rosana Peir{\'o} and Rafael Marcos-Gragera and Carmen Navarro and Gemma Casta{\~n}o and Marina Poll{\'a}n and Ana Maria Garc{\'\i}a and Manolis Kogevinas}, title = {P046 Occupational exposures and gastric cancer risk in the MCC-spain case-control study}, volume = {73}, number = {Suppl 1}, pages = {A136--A136}, year = {2016}, doi = {10.1136/oemed-2016-103951.370}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective To explore the relationship between gastric cancer (GC) and occupational exposures.Methods A total of 382 incident GC cases and 2,846 randomly selected population controls with occupational information were included from the MCC-Spain study, a population-based multicase-control study. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the MatEmEsp Job Exposure Matrix. ORs and their 95\% confidence intervals (CI) were estimated by unconditional logistic regression adjusting for matching variables and education.Results In men, a statistically significant increased risk of GC, was found for {\textquoteleft}Employed skilled workers in agricultural activities{\textquoteright} (OR 4.4) and a borderline association was found for {\textquoteleft}miners and quarry workers{\textquoteright} (OR 1.8, 95\% CI: 0.9 to 3.4). Regarding occupational exposures, a statistically significant association was found for long term exposure (\>10 years) to {\textquoteleft}insecticides{\textquoteright} in women (OR 2.68) and a borderline association was found in men (OR 1.43, 95\% CI: 0.94 to 2.17). In men, a statistically significant increased risk of GC for the highest level of exposure to {\textquoteleft}ioninzing radiation{\textquoteright} (2.08), and {\textquoteleft}silica dust{\textquoteright} (OR1.52) was also found. In women, statistically significant associations were found for the highest level of exposure to some dusty exposures such as {\textquoteleft}flour dust{\textquoteright} (OR 1.76), or {\textquoteleft}other mineral dust different from silica{\textquoteright} (OR 2.07). A borderline association was found in women for other dusty exposures such as {\textquoteleft}paper pulp\&dust{\textquoteright} (OR 3.22, 95\% CI: 0.99 to 10.45), and non-significant increases of risk were found for {\textquoteleft}leather dust{\textquoteright} (OR 2.30, 95\% CI: 0.58 to 9.17) and {\textquoteleft}textile dust{\textquoteright} (OR 2.30, 95\% CI: 0.59 to 9.92).Conclusions This study supports the relationship previously suggested between GC and ionising radiation, pesticides or occupational exposure to dusty environments.}, issn = {1351-0711}, URL = {https://oem.bmj.com/content/73/Suppl_1/A136.1}, eprint = {https://oem.bmj.com/content/73/Suppl_1/A136.1.full.pdf}, journal = {Occupational and Environmental Medicine} }