RT Journal Article
SR Electronic
T1 P021 Heat working environment and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain case control study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP A126
OP A126
DO 10.1136/oemed-2016-103951.346
VO 73
IS Suppl 1
A1 Alba-Hidalgo, Miguel-Angel
A1 Alguacil, Juan
A1 Costas, Laura
A1 Gracia, Esther
A1 Garrido, Juan-Antonio
A1 Aragonés, Nuria
A1 Pérez-Gómez, Beatriz
A1 Molina, Antonio-José
A1 Llorca, Javier
A1 Moreno, Víctor
A1 Altzibar, Jone-Miren
A1 Burgui, Rosana
A1 Sanjose, Silvia de
A1 Jiménez-Moleón, José-Juan
A1 Fernández-Tardón, Guillermo
A1 Capelo, Rocío
A1 Peiró, Rosana
A1 Marcos-Gragera, Rafael
A1 Chirlaque, María-Dolores
A1 Castaño-Vinyals, Gemma
A1 Pollán, Marina
A1 García, Ana-María
A1 Kogevinas, Manolis
YR 2016
UL http://oem.bmj.com/content/73/Suppl_1/A126.2.abstract
AB Occupational exposure to heat can affect the absorption of carcinogenic chemicals into the body, and the metabolism of sexual hormones. We explored the association between occupational exposure to heat and breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study.Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 LLC, 1070 prostate, and 382 stomach cancer cases. Heat working environment from either natural or artificial sources was assessed with the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geographic area, BMI (colorectal, prostate), smoking (stomach, colorectal), menopause (breast) and number of alive children (breast) were fit to estimate Odds Ratios (OR) and 95% Confidence Limits (95 CL).Results Prostate cancer risk was over two and a half fold higher among men working for more than 10 years on a heat working environment than among who did not. Women working more than 10 years in occupations entailing heat exposure showed a higher risk of having breast cancer (OR: 1.3, 95% CL 1.04–1.7). The same figures where obtained for those working in occupations with higher probability*intensity of the exposure. Significant higher risk associations were also observed for colorectal cancer, among both men and women separately. While for stomach cancer, statistical significance was obtained only among men. LLC showed a suggestion of an association for both men and women.Our results provide further support to the hypothesis that working in a heat environment might be a risk factor for chemically and hormone related cancers.