PT  - JOURNAL ARTICLE
AU  - Alba-Hidalgo, Miguel-Angel
AU  - Alguacil, Juan
AU  - Costas, Laura
AU  - Gracia, Esther
AU  - Garrido, Juan-Antonio
AU  - Aragonés, Nuria
AU  - Pérez-Gómez, Beatriz
AU  - Molina, Antonio-José
AU  - Llorca, Javier
AU  - Moreno, Víctor
AU  - Altzibar, Jone-Miren
AU  - Burgui, Rosana
AU  - Sanjose, Silvia de
AU  - Jiménez-Moleón, José-Juan
AU  - Fernández-Tardón, Guillermo
AU  - Capelo, Rocío
AU  - Peiró, Rosana
AU  - Marcos-Gragera, Rafael
AU  - Chirlaque, María-Dolores
AU  - Castaño-Vinyals, Gemma
AU  - Pollán, Marina
AU  - García, Ana-María
AU  - Kogevinas, Manolis
TI  - P021 Heat working environment and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain case control study
AID  - 10.1136/oemed-2016-103951.346
DP  - 2016 Sep 01
TA  - Occupational and Environmental Medicine
PG  - A126--A126
VI  - 73
IP  - Suppl 1
4099  - http://oem.bmj.com/content/73/Suppl_1/A126.2.short
4100  - http://oem.bmj.com/content/73/Suppl_1/A126.2.full
SO  - Occup Environ Med2016 Sep 01; 73
AB  - Occupational exposure to heat can affect the absorption of carcinogenic chemicals into the body, and the metabolism of sexual hormones. We explored the association between occupational exposure to heat and breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study.Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 LLC, 1070 prostate, and 382 stomach cancer cases. Heat working environment from either natural or artificial sources was assessed with the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geographic area, BMI (colorectal, prostate), smoking (stomach, colorectal), menopause (breast) and number of alive children (breast) were fit to estimate Odds Ratios (OR) and 95% Confidence Limits (95 CL).Results Prostate cancer risk was over two and a half fold higher among men working for more than 10 years on a heat working environment than among who did not. Women working more than 10 years in occupations entailing heat exposure showed a higher risk of having breast cancer (OR: 1.3, 95% CL 1.04–1.7). The same figures where obtained for those working in occupations with higher probability*intensity of the exposure. Significant higher risk associations were also observed for colorectal cancer, among both men and women separately. While for stomach cancer, statistical significance was obtained only among men. LLC showed a suggestion of an association for both men and women.Our results provide further support to the hypothesis that working in a heat environment might be a risk factor for chemically and hormone related cancers.