TY - JOUR T1 - P025 Lung cancer risk among firefighters when accounting for tobacco smoking – preliminary results from a pooled analysis of case-control studies from europe, canada, new zealand and china JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - A128 LP - A128 DO - 10.1136/oemed-2016-103951.350 VL - 73 IS - Suppl 1 AU - Carolina Bigert AU - Per Gustavsson AU - Kurt Straif AU - Dirk Taeger AU - Beate Pesch AU - Benjamin Kendzia AU - Joachim Schüz AU - Isabelle Stücker AU - Florence Guida AU - Irene Brüske AU - Heinz-Erich Wichmann AU - Angela C Pesatori AU - Maria Teresa Landi AU - Neil Caporaso AU - Lap Ah Tse AU - Ignatius Tak-sun Yu AU - Jack Siemiatycki AU - Jérôme Lavoué AU - Lorenzo Richardi AU - Dario Mirabelli AU - Lorenzo Simonato AU - Karl-Heinz Jöckel AU - Wolfgang Ahrens AU - Hermann Pohlabeln AU - Adonina Tardón AU - David Zaridze AU - John K Field AU - Andrea‘t Mannetje AU - Neil Pearce AU - John McLaughlin AU - Paul Demers AU - Neonila Szeszenia-Dabrowska AU - Jolanta Lissowska AU - Peter Rudnai AU - Eleonora Fabianova AU - Rodica Stanescu Dumitru AU - Vladimir Bencko AU - Lenka Foretova AU - Vladimir Janout AU - Paolo Boffetta AU - Susan Peters AU - Roel Vermeulen AU - Hans Kromhout AU - Thomas Brüning AU - Ann C Olsson Y1 - 2016/09/01 UR - http://oem.bmj.com/content/73/Suppl_1/A128.1.abstract N2 - Objectives Firefighters are potentially exposed to a wide variety of chemical compounds during the course of their work and inhalation is considered to be the major source of exposure. A large number of human carcinogens have been detected in smoke at fires. The aim was to investigate the risk of lung cancer among firefighters, while controlling for smoking habits.Methods We used data from the SYNERGY project including pooled information on lifetime work histories and smoking habits for 14,748 male lung cancer cases and 17,543 controls from 14 case-control studies conducted in Europe, Canada, New Zealand and China. There were 190 men who had ever worked as a firefighter (based on ISCO-68), among them 86 cases and 104 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression, adjusted for study, age, smoking, and ever employment in an occupation with established lung cancer risk.Results We observed no increased risk of lung cancer in firefighters, neither before (OR = 1.03, 95% CI: 0.77–1.38) nor after (OR = 0.95, 95% CI: 0.68–1.32) adjustment for smoking and exposure to other occupational lung carcinogens. There was no evidence of a trend of increasing lung cancer risk with increasing duration of work as a firefighter (p = 0.58) and no significant heterogeneity in lung cancer risk among firefighters across the studies. None of the major histological subtypes of lung cancer was associated with work as a firefighter.Conclusions We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter, when lifetime history of tobacco smoking and exposure to other occupational lung carcinogens was taken into account. ER -