RT Journal Article
SR Electronic
T1 P025 Lung cancer risk among firefighters when accounting for tobacco smoking – preliminary results from a pooled analysis of case-control studies from europe, canada, new zealand and china
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP A128
OP A128
DO 10.1136/oemed-2016-103951.350
VO 73
IS Suppl 1
A1 Carolina Bigert
A1 Per Gustavsson
A1 Kurt Straif
A1 Dirk Taeger
A1 Beate Pesch
A1 Benjamin Kendzia
A1 Joachim Schüz
A1 Isabelle Stücker
A1 Florence Guida
A1 Irene Brüske
A1 Heinz-Erich Wichmann
A1 Angela C Pesatori
A1 Maria Teresa Landi
A1 Neil Caporaso
A1 Lap Ah Tse
A1 Ignatius Tak-sun Yu
A1 Jack Siemiatycki
A1 Jérôme Lavoué
A1 Lorenzo Richardi
A1 Dario Mirabelli
A1 Lorenzo Simonato
A1 Karl-Heinz Jöckel
A1 Wolfgang Ahrens
A1 Hermann Pohlabeln
A1 Adonina Tardón
A1 David Zaridze
A1 John K Field
A1 Andrea‘t Mannetje
A1 Neil Pearce
A1 John McLaughlin
A1 Paul Demers
A1 Neonila Szeszenia-Dabrowska
A1 Jolanta Lissowska
A1 Peter Rudnai
A1 Eleonora Fabianova
A1 Rodica Stanescu Dumitru
A1 Vladimir Bencko
A1 Lenka Foretova
A1 Vladimir Janout
A1 Paolo Boffetta
A1 Susan Peters
A1 Roel Vermeulen
A1 Hans Kromhout
A1 Thomas Brüning
A1 Ann C Olsson
YR 2016
UL http://oem.bmj.com/content/73/Suppl_1/A128.1.abstract
AB Objectives Firefighters are potentially exposed to a wide variety of chemical compounds during the course of their work and inhalation is considered to be the major source of exposure. A large number of human carcinogens have been detected in smoke at fires. The aim was to investigate the risk of lung cancer among firefighters, while controlling for smoking habits.Methods We used data from the SYNERGY project including pooled information on lifetime work histories and smoking habits for 14,748 male lung cancer cases and 17,543 controls from 14 case-control studies conducted in Europe, Canada, New Zealand and China. There were 190 men who had ever worked as a firefighter (based on ISCO-68), among them 86 cases and 104 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression, adjusted for study, age, smoking, and ever employment in an occupation with established lung cancer risk.Results We observed no increased risk of lung cancer in firefighters, neither before (OR = 1.03, 95% CI: 0.77–1.38) nor after (OR = 0.95, 95% CI: 0.68–1.32) adjustment for smoking and exposure to other occupational lung carcinogens. There was no evidence of a trend of increasing lung cancer risk with increasing duration of work as a firefighter (p = 0.58) and no significant heterogeneity in lung cancer risk among firefighters across the studies. None of the major histological subtypes of lung cancer was associated with work as a firefighter.Conclusions We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter, when lifetime history of tobacco smoking and exposure to other occupational lung carcinogens was taken into account.