RT Journal Article
SR Electronic
T1 Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 368
OP 377
DO 10.1136/oemed-2015-103177
VO 73
IS 6
A1 Francesca Mattei
A1 Silvia Liverani
A1 Florence Guida
A1 Mireille Matrat
A1 Sylvie Cenée
A1 Lamiae Azizi
A1 Gwenn Menvielle
A1 Marie Sanchez
A1 Corinne Pilorget
A1 Bénédicte Lapôtre-Ledoux
A1 Danièle Luce
A1 Sylvia Richardson
A1 Isabelle Stücker
A1 ICARE Study Group
YR 2016
UL http://oem.bmj.com/content/73/6/368.abstract
AB Background The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used simultaneously, it is difficult to assess the role of individual substances.Objectives The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.Methods We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.Results After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.Conclusions Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.