TY - JOUR T1 - 0373 Pooling case-control studies for enhanced evidence on occupational risk factors in lung cancer research – the SYNERGY project JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - A46 LP - A47 DO - 10.1136/oemed-2014-102362.144 VL - 71 IS - Suppl 1 AU - Ann Olsson AU - Hans Kromhout AU - Roel Vermeulen AU - Susan Peters AU - Beate Pesch AU - Thomas Behrens AU - Benjamin Kendzia AU - Joachim Schüz AU - Kurt Straif Y1 - 2014/06/01 UR - http://oem.bmj.com/content/71/Suppl_1/A46.3.abstract N2 - Objectives Explore quantitative exposure-response association for exposure to asbestos, crystalline silica, nickel, chromium and polycyclic aromatic hydrocarbons in the general population; further study effects on specific cell types and potential interaction with smoking and co-occurring occupational exposures. Method Fourteen studies from Europe and Canada were pooled including 17 700 lung cancer cases and 21 800 controls with detailed information on tobacco habits and lifetime occupations. A quantitative job-exposure-matrix (SYN-JEM) was developed based on more than 350.000 exposure measurements from the participating countries. Different model specifications were compared to predict historical job-, time-, and region-specific exposure levels. Individual exposure levels were calculated for each subject by linking the SYN-JEM with the individual occupational histories. Unconditional logistic regression models were fitted to estimate odds ratios, 95% confidence intervals, and trends. Results We observed exposure-response relationships with increasing duration and cumulative exposure for all agents and generally saw a stronger effect for squamous- and small cell lung carcinomas than for adenocarcinomas. Smoking and simultaneous exposure to other occupational exposures exerted a minor confounding effect on the risk estimates. The effect modifications with smoking tended to be supra-additive. Conclusions SYNERGY adds valuable knowledge to the field of occupational cancer epidemiology, and underlines the importance to collect data on histology, and lifelong information on occupational exposures and smoking. ER -