TY - JOUR T1 - A community study of the effect of polycyclic aromatic hydrocarbon metabolites on heart rate variability based on the Framingham risk score JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 338 LP - 345 DO - 10.1136/oemed-2013-101884 VL - 71 IS - 5 AU - Yingying Feng AU - Huizhen Sun AU - Yuanchao Song AU - Junzhe Bao AU - Xiji Huang AU - Jian Ye AU - Jing Yuan AU - Weihong Chen AU - David C Christiani AU - Tangchun Wu AU - Xiaomin Zhang Y1 - 2014/05/01 UR - http://oem.bmj.com/content/71/5/338.abstract N2 - Objectives To investigate the effects of the urinary metabolite profiles of background exposure to the atmospheric pollutants polycyclic aromatic hydrocarbon (PAH) and Framingham risk score (FRS), which assesses an individual's cardiovascular disease risk, on heart rate variability (HRV). Methods The study conducted from April to May 2011 in Wuhan, China, included 1978 adult residents with completed questionnaires, physical examinations, blood and urine samples, and 5-min HRV indices (including SD of all normal to normal intervals (SDNN), root mean square successive difference (rMSSD), low frequency (LF), high frequency (HF) and their ratio (LF/HF), and total power) obtained from 3-channel Holter monitor. 12 urinary PAH metabolites were measured by gas chromatography–mass spectrometry. FRS was calculated by age, sex, lipid profiles, blood pressure, diabetes and smoking status. Linear regression models were constructed after adjusting for potential confounders. Results Elevated total concentration of hydroxynaphthalene (ΣOHNa) was significantly associated, in a dose–responsive manner, with decreased SDNN and LF/HF (ptrend=0.014 and 0.007, respectively); elevated total concentration of hydroxyfluorene (ΣOHFlu) was significantly associated with reduced SDNN, LF and LF/HF (ptrend=0.027, 0.003, and <0.0001, respectively); and elevated total concentration of all PAH metabolites (ΣOH-PAHs) was associated with decreased LF and LF/HF (ptrend=0.005 and <0.0001, respectively). Moreover, increasing quartiles of FRS were significantly associated with decreased HRV indices, except LF/HF (all ptrend<0.0001). Interestingly, individuals in low-risk subgroups had greater decreases in SDNN, LF and LF/HF in relation to ΣOH-PAHs, ΣOHNa and ΣOHFlu than those in high-risk subgroups (all p<0.05). Conclusions Environmental PAH exposure may differentially affect HRV based on individual coronary risk profiles. ER -