RT Journal Article
SR Electronic
T1 0127 Pesticide use and relative telomere length in the Agricultural Health Study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP A14
OP A15
DO 10.1136/oemed-2014-102362.45
VO 71
IS Suppl 1
A1 Andreotti, Gabriella
A1 Hoppin, Jane
A1 Savage, Sharon
A1 Hou, Lifang
A1 Baccarelli, Andrea
A1 Hoxha, Mirjam
A1 Koutros, Stella
A1 Sandler, Dale
A1 Alavanja, Michael
A1 Beane Freeman, Laura
YR 2014
UL http://oem.bmj.com/content/71/Suppl_1/A14.3.abstract
AB Objectives Epidemiologic studies have linked pesticide use to various health outcomes, including cancer, but underlying mechanisms remain unclear. In a previous analysis from the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators in the US, use of certain pesticides was linked to shorter relative telomere length (RTL) measured in buccal cell DNA. In this analysis we examined the associations between occupational pesticide use and RTL measured in blood DNA. Method We conducted an analysis of 80 pesticides and RTL in 568 cancer-free male participants aged 31–94 years in the AHS. We used self-reported pesticide use information collected at study enrollment (1993–1997) and two follow-up questionnaires administered approximately 5 years apart to construct exposure metrics, including intensity-weighted lifetime days (lifetime days*intensity score). Blood samples were collected in 2006–2008, and RTL was measured in DNA using qPCR. Multivariable linear regression was used to evaluate the associations between individual pesticide use and RTL, adjusting for age at blood draw and other pesticides associated with RTL. Results Increasing tertiles of intensity-weighted days of alachlor were associated with longer RTL (p-trend = 0.01). In contrast, increasing tertiles of intensity-weighted days of 2,4-D (p-trend = 0.05), diazinon (p-trend = 0.01) and aldrin (p-trend = 0.01) were associated with shorter RTL. Conclusions We found two herbicides (alachlor, 2,4-D) and two insecticides (diazinon, aldrin) significantly associated with alterations in RTL. These pesticides have been linked to increased cancer risk in epidemiological and/or animal studies. Consistent with our finding, shorter RTL with 2,4-D use was previously observed in an analysis of buccal cells in the AHS.