TY - JOUR T1 - 0383 Use of an O*NET based job exposure matrix to predict prevalence of Carpal Tunnel Syndrome in a large pooled cohort JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - A48 LP - A49 DO - 10.1136/oemed-2014-102362.150 VL - 71 IS - Suppl 1 AU - Ann Marie Dale AU - Angelique Zeringue AU - Carisa Harris-Adamson AU - Matt Thiese AU - Stephen Bao AU - Sue Burt AU - Linda Merlino AU - Arun Garg AU - Ellen Eisen AU - Fred Gerr AU - Kurt Hegmann AU - Jay Kapellusch AU - David Rempel AU - Barbara Silverstein AU - Bradley Evanoff Y1 - 2014/06/01 UR - http://oem.bmj.com/content/71/Suppl_1/A48.3.abstract N2 - Objectives To determine if job title based physical exposure measures predicted prevalent carpal tunnel syndrome (CTS) in a large pooled cohort of workers. Method We pooled baseline examination data from six prospective cohort studies, restricting analyses to those employed at least 1 year. CTS was defined as median neuropathy plus typical symptoms. Physical exposure estimates for static strength, dynamic strength, time spent making repetitive motions, and time handling objects were extracted from the Occupational Network (O*NET) database using Standard Occupational Classification codes based on reported job title. Three exposure categories of high force/ high repetition, low force/ low repetition, and mixed high and low exposures were entered into logistic regression models adjusting for age, gender, body mass index (BMI), diabetes, rheumatoid arthritis, employed time and study site. Results Of 3562 in the pooled cohort, 7.6% met a prevalent CTS definition with mean employed time of 7.9 years (SD 8.2). Compared to subjects with low job requirements for dynamic strength and repetitive motion, those with mixed exposures or high exposures showed increased prevalence of CTS (OR 1.46; 95% CI: 1.01–2.11 and OR 2.32; 95% CI: 1.15–4.67, respectively). Similar dose dependent associations of combined exposures were shown for all exposure combinations tested, with high/high combinations having the largest effect sizes (OR range 2.32–3.17) relative to the low force/low repetition exposure combinations. Conclusions Use of job-title based exposures was useful for demonstrating associations with prevalent CTS. Jobs with combined high exposures of force and repetition showed consistently greater risk of CTS compared to jobs with lower exposure levels. ER -