@article {McLean253, author = {Dave McLean and Sarah Fleming and Michelle C Turner and Laurel Kincl and Lesley Richardson and Geza Benke and Brigitte Schlehofer and Klaus Schlaefer and Marie-Elise Parent and Martine Hours and Daniel Krewski and Martie van Tongeren and Siegal Sadetzki and Jack Siemiatycki and Elisabeth Cardis}, title = {Occupational solvent exposure and risk of meningioma: results from the INTEROCC multicentre case{\textendash}control study}, volume = {71}, number = {4}, pages = {253--258}, year = {2014}, doi = {10.1136/oemed-2013-101780}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective To examine associations between occupational exposure to selected organic solvents and meningioma. Methodology A multicentre case{\textendash}control study conducted in seven countries, including 1906 cases and 5565 controls. Occupational exposure to selected classes of organic solvents (aliphatic and alicyclic hydrocarbons, aromatic hydrocarbons, chlorinated hydrocarbons and {\textquoteleft}other{\textquoteright} organic solvents) or seven specific solvents (benzene, toluene, trichloroethylene, perchloroethylene, 1,1,1-trichloroethylene, methylene chloride and gasoline) was assessed using lifetime occupational histories and a modified version of the FINJEM job-exposure matrix (INTEROCC-JEM). Study participants were classified as {\textquoteleft}exposed{\textquoteright} when they had worked in an occupation for at least 1 year, with a 5-year lag, in which the estimated prevalence of exposure was 25\% or greater in the INTEROCC-JEM. Associations between meningioma and each of the solvent exposures were estimated using conditional logistic regression, adjusting for potential confounders. Results A total of 6.5\% of study participants were ever exposed to {\textquoteleft}any{\textquoteright} solvent, with a somewhat greater proportion of controls (7\%) ever exposed compared with cases (5\%), but only one case was ever exposed to any chlorinated hydrocarbon (1,1,1-trichloroethane). No association was observed between any of the organic solvents and meningioma, in either men or women, and no dose{\textendash}response relationships were observed in internal analyses using either exposure duration or cumulative exposure. Discussion We found no evidence that occupational exposure to these organic solvents is associated with meningioma.}, issn = {1351-0711}, URL = {https://oem.bmj.com/content/71/4/253}, eprint = {https://oem.bmj.com/content/71/4/253.full.pdf}, journal = {Occupational and Environmental Medicine} }