RT Journal Article
SR Electronic
T1 Adverse effects of low occupational cadmium exposure on renal and oxidative stress biomarkers in solderers
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 108
OP 113
DO 10.1136/oemed-2012-100887
VO 70
IS 2
A1 Ramona Hambach
A1 Dominique Lison
A1 Patrick D'Haese
A1 Joost Weyler
A1 Guido François
A1 Antoon De Schryver
A1 Begoña Manuel-Y-Keenoy
A1 Ulrik Van Soom
A1 Tine Caeyers
A1 Marc van Sprundel
YR 2013
UL http://oem.bmj.com/content/70/2/108.abstract
AB Objectives Recent studies suggest adverse health effects after low exposure to cadmium (Cd). Brazing with Cd-containing solder exposes workers to Cd. The purpose of this study was to assess: (1) indicators of Cd exposure in blood (Cd-B)/ urine (Cd-U); (2) the association between Cd-B, Cd-U and renal and oxidative stress biomarkers. Methods In this cross-sectional study Cd-B, Cd-U, renal (ie, N-acetyl-β-D-glucosaminidase/urinary intestinal alkaline phosphatase (IAP)/microalbumin/beta-2-microglobulin/retinol binding protein and oxidative stress markers (ie, derivatives of reactive oxygen metabolites/glutathione peroxidase/superoxide dismutase (SOD)/ advanced oxidation protein products/8-hydroxy-2′-deoxyguanosin/8-isoprostanes) were determined in 36 solderers. Results Multiple linear regression analysis adjusting for age and pack-years of smoking show that IAP is statistically significantly associated with Cd-B (B=0.24; SE=0.11) and Cd-U (B=0.15; SE=0.07). Also SOD is statistically significantly associated with Cd-B (B=62.96; SE=29.62). The association between SOD and Cd-U is of borderline statistical significance (B=37.69; SE=19.59). Conclusions While there is still some debate as whether the Cd-induced tubular effects are reversible or not, IAP and SOD appear as sensitive and potentially useful early biomarkers for the health surveillance of workers exposed to low levels of Cd.