TY - JOUR T1 - Adverse effects of low occupational cadmium exposure on renal and oxidative stress biomarkers in solderers JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 108 LP - 113 DO - 10.1136/oemed-2012-100887 VL - 70 IS - 2 AU - Ramona Hambach AU - Dominique Lison AU - Patrick D'Haese AU - Joost Weyler AU - Guido François AU - Antoon De Schryver AU - Begoña Manuel-Y-Keenoy AU - Ulrik Van Soom AU - Tine Caeyers AU - Marc van Sprundel Y1 - 2013/02/01 UR - http://oem.bmj.com/content/70/2/108.abstract N2 - Objectives Recent studies suggest adverse health effects after low exposure to cadmium (Cd). Brazing with Cd-containing solder exposes workers to Cd. The purpose of this study was to assess: (1) indicators of Cd exposure in blood (Cd-B)/ urine (Cd-U); (2) the association between Cd-B, Cd-U and renal and oxidative stress biomarkers. Methods In this cross-sectional study Cd-B, Cd-U, renal (ie, N-acetyl-β-D-glucosaminidase/urinary intestinal alkaline phosphatase (IAP)/microalbumin/beta-2-microglobulin/retinol binding protein and oxidative stress markers (ie, derivatives of reactive oxygen metabolites/glutathione peroxidase/superoxide dismutase (SOD)/ advanced oxidation protein products/8-hydroxy-2′-deoxyguanosin/8-isoprostanes) were determined in 36 solderers. Results Multiple linear regression analysis adjusting for age and pack-years of smoking show that IAP is statistically significantly associated with Cd-B (B=0.24; SE=0.11) and Cd-U (B=0.15; SE=0.07). Also SOD is statistically significantly associated with Cd-B (B=62.96; SE=29.62). The association between SOD and Cd-U is of borderline statistical significance (B=37.69; SE=19.59). Conclusions While there is still some debate as whether the Cd-induced tubular effects are reversible or not, IAP and SOD appear as sensitive and potentially useful early biomarkers for the health surveillance of workers exposed to low levels of Cd. ER -