PT - JOURNAL ARTICLE AU - A A Ismail AU - T E Bodner AU - D S Rohlman TI - Neurobehavioral performance among agricultural workers and pesticide applicators: a meta-analytic study AID - 10.1136/oemed-2011-100204 DP - 2012 Jul 01 TA - Occupational and Environmental Medicine PG - 457--464 VI - 69 IP - 7 4099 - http://oem.bmj.com/content/69/7/457.short 4100 - http://oem.bmj.com/content/69/7/457.full SO - Occup Environ Med2012 Jul 01; 69 AB - Chronic low level exposure of agricultural workers and applicators to pesticides has been found to be associated with different degrees of decrement in cognitive and psychomotor functions. The goal of this study was to use meta-analysis to (1) identify and quantify neurobehavioral deficits among agricultural workers and pesticide applicators, and (2) analyse the potential confounders or moderators of these neurobehavioral deficits. Seventeen studies, reporting on 21 independent cohort groups, were included in the meta-analysis. These studies involved 16 neuropsychological tests providing 23 different performance measures that constitute the neurobehavioral constructs. All tests and measures of the neurobehavioral functions of attention, visuomotor integration, verbal abstraction and perception constructs showed significant decrements for exposed participants. One out of three tests of memory, two of five tests of sustained attention, and four of eight tests of motor speed constructs also showed significant decrements. Nine out of these 15 effect size distributions demonstrated significant heterogeneity across cohorts. A search for cohort-level variables (eg, agricultural workers vs applicators, duration of exposure, age and percentage of male participants) to explain this heterogeneity was largely unsuccessful. However, for one test, Block Design, the duration of exposure was positively associated with performance decrements. Furthermore, it was also found that performance decrements on this test were smaller for older participants. Increasing the number of studies and using more consistent methodologies in field studies are needed.