RT Journal Article
SR Electronic
T1 Night shift work characteristics and 6-sulfatoxymelatonin (MT6s) in rotating night shift nurses and midwives
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 339
OP 346
DO 10.1136/oemed-2011-100273
VO 69
IS 5
A1 Beata Peplonska
A1 Agnieszka Bukowska
A1 Jolanta Gromadzinska
A1 Wojciech Sobala
A1 Edyta Reszka
A1 Jenny-Anne Lie
A1 Helge Kjuus
A1 Wojciech Wasowicz
YR 2012
UL http://oem.bmj.com/content/69/5/339.abstract
AB Objectives Synthesis of melatonin follows a circadian cycle, with high melatonin levels during the night and low levels during the day. Light exposure at night has been hypothesised as one of potential mechanisms of breast carcinogenesis in the night shift workers through inhibition of melatonin synthesis. The aim of the study was to examine a number of determinants for night shift work in relation to 6-sulfatoxymelatonin (MT6s), primary melatonin metabolite.Methods The cross-sectional study included 354 nurses and midwives (aged 40–60 years) currently working on rotating night shifts and 370 working days only. Data from questionnaires and 1-week diaries were used to characterise current job and total occupational history. Associations between rotating night shift work characteristics and MT6s (creatinine adjusted) in spot morning urine were tested in multiple linear regression models.Results No significant differences were found for MT6s concentrations between women currently working on rotating night shifts and those working only day shifts (means 47.2 vs 45.7 ng/mg Cr, respectively). The adjusted means among rotating night shift nurses and midwives varied depending on the department of employment, from 35.1 ng/mg Cr in neonatology to 68.2 ng/mg Cr in the orthopaedics department. Women working eight or more night shifts per month had significantly lower MT6s levels than those having fewer night shifts per month (37.9 vs 47.4 ng/mg Cr, respectively). Total night shift work history was not associated with MT6s.Conclusions The results of this study indicate that working eight or more night shifts per month may disrupt the synthesis of melatonin.