TY - JOUR T1 - Single high flow exhaled nitric oxide is an imperfect proxy for distal nitric oxide JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 519 LP - 520 DO - 10.1136/oemed-2013-101458 VL - 70 IS - 7 AU - Sandrah P Eckel AU - Muhammad T Salam Y1 - 2013/07/01 UR - http://oem.bmj.com/content/70/7/519.2.abstract N2 - The fractional concentration of exhaled nitric oxide (FeNO) has been used as a non-invasive biomarker of airway response to inhaled toxic exposures in both population-based and occupational studies. Results have been mixed, but a compelling finding is the 60% decrease (95% CI 54 to 66) and subsequent 130% increase (95% CI 63 to 225) in FeNO observed in a quasi-experimental study of FeNO in a group of healthy young adult volunteers before, during and after the 2008 Beijing Olympic games air pollution control measures.1 Methodological developments now allow for the assessment of NO from proximal and distal airway compartment sources. The ability to non-invasively differentiate inflammation in two lower respiratory tract compartments may provide a practical method to gain insights into the effects of inhaled toxins. Using this approach, … ER -