RT Journal Article SR Electronic T1 Cancer morbidity and quartz exposure in Swedish iron foundries JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP A39 OP A39 DO 10.1136/oemed-2011-100382.127 VO 68 IS Suppl 1 A1 Håkan Westberg A1 Lena Andersson A1 Carl-Göran Ohlson A1 Ing-Lisss Bryngelsson A1 Yen Ngo YR 2011 UL http://oem.bmj.com/content/68/Suppl_1/A39.3.abstract AB Objectives The aim of this study was to determine cancer morbidity for Swedish iron foundry workers with special reference to quartz exposure. Methods The cohort of 3 045 men employed between 1913 and 2005 and with >1 year of exposure was followed for cancer morbidity from 1958 to 2004. Standardised incidence ratios (SIRs) with 95% CIs were determined by comparing the observed number of incident cancers to the Swedish cancer register. Exposure measures were assessed from personal files and a quartz measurement database of 2 822 air samples. Results Overall cancer morbidity was not increased (SIR 1.00; 95% CI 0.90 to 1.11), however lung cancer was significantly enhanced (SIR 1.61; 95 % CI 1.20 to 2.12). Dose response for lung cancer was determined for duration of employment, duration of exposures and cumulative quartz for latency periods >20 years. Significant findings for lung cancer and cumulative quartz were determined for quartz doses of 1–2 mg/m3 *year, SIR 2.88 (95% CI 1.44 to 5.16), and for >2 mg/m3 *year a SIR of 1.68 (95% CI 1.07 to 2.52). For cancer sites with at least 5 observed cases and a SIR>1.25, non-significant risks were determined for liver, larynx, testis, the urinary organs, muscle of the connective tissue and lymphatic leukemia. Conclusions An increased lung cancer risk for Swedish foundry workers related to quartz exposure was determined.