RT Journal Article
SR Electronic
T1 Lung cancer risk and radon exposure in a cohort of iron ore miners in Malmberget, Sweden
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 519
OP 525
DO 10.1136/oem.2009.047449
VO 67
IS 8
A1 Håkan Jonsson
A1 Ingvar A Bergdahl
A1 Gustav Åkerblom
A1 Kåre Eriksson
A1 Kurt Andersson
A1 Leif Kågström
A1 Bengt Järvholm
A1 Lena Damber
YR 2010
UL http://oem.bmj.com/content/67/8/519.abstract
AB Objectives Lung cancer caused by radon in miners is a well-known risk. However, the risk estimates vary between studies and between mines. We have studied the dose response–relationship in a Swedish iron ore mine where two other studies have previously reached different risk estimates. As this mine has relatively low radon levels, the results are highly relevant for risk estimation in non-uranium underground mines.Methods A new cohort of 5486 male workers employed from 1923 to 1996 was established. Cumulative radon exposures were assessed based on a large number of measurements, including reconstructions of historical conditions. 122 lung cancer cases occurred during the follow-up period of 1958–2000.Results The average cumulative exposure in underground workers was 32 kBq year/m3 (65 working level months (WLM)), experienced over 14.6 years. The excess RR (ERR) per kBq year/m3 was 0.046 (95% CI 0.015 to 0.077; 0.022 ERR/WLM). Confounding by quartz may affect these results but appears to account only for 10–20% of the risk. The results for squamous cell and small cell lung cancer were 0.049 and 0.072, respectively. However, no increased risk was observed for adenocarcinoma (0.000 ERR per kBq year/m3, 95% CI −0.017 to 0.017).Conclusion Our overall risk estimate is about half of that found in the first Malmberget study but twice that found in the same cohort in the previously published pooled analysis. Radon did not increase the risk for adenocarcinoma in the lung.