TY - JOUR T1 - GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 308 LP - 308 DO - 10.1136/oem.2010.063560 VL - 68 IS - 4 AU - Chris Carlsten AU - Anne Dybuncio AU - Allan Becker AU - Moira Chan-Yeung AU - Michael Brauer Y1 - 2011/04/01 UR - http://oem.bmj.com/content/68/4/308.abstract N2 - We recently reported1 on the risk of incident asthma associated with traffic-related air pollution in a high-risk birth cohort in Vancouver, British Columbia. We have now examined the effect of two common polymorphisms in the glutathione-s-transferase P1 (GSTP1) gene that is known to metabolise oxidative species and which has been shown previously to modify risk of allergic disease associated with nitrogen dioxide (NO2) exposure.2At 7 years of age, 173 children were assessed for asthma by paediatric allergists and peripheral blood was obtained from these children and their parents. DNA was genotyped by the Illumina BeadArray system (Illumina, San Diego, California, USA) following the manufacturer's … ER -