TY - JOUR T1 - A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 105 LP - 110 DO - 10.1136/oem.2008.039560 VL - 66 IS - 2 AU - F G B G J van Rooy AU - L A M Smit AU - R Houba AU - V A C Zaat AU - J M Rooyackers AU - D J J Heederik Y1 - 2009/02/01 UR - http://oem.bmj.com/content/66/2/105.abstract N2 - Objectives: Four diacetyl workers were found to have bronchiolitis obliterans syndrome. Exposures, respiratory symptoms, lung function and exposure–response relationships were investigated. Methods: 175 workers from a plant producing diacetyl between 1960 and 2003 were investigated. Exposure data were used to model diacetyl exposure. Lung function and questionnaire data on respiratory symptoms were compared to a general population sample and respiratory symptoms to an internal reference group. Results: Workers were potentially exposed to acetoin, diacetyl, acetaldehyde and acetic acid. Historic diacetyl exposure ranged from 1.8 to 351 mg/m3, and from 3 to 396 mg/m3 for specific tasks. Diacetyl workers reported significantly more respiratory symptoms compared to the general population sample (continuous trouble with breathing (prevalence ratio (PR) = 2.6; 95% CI 1.3 to 5.1), daily cough (PR = 1.5; 95% CI 1.1 to 2.1), asthma attack (ever) (PR = 2.0; 95% CI 1.2 to 3.4), doctor diagnosed asthma (PR = 2.2; 95% CI 1.3 to 3.8) and asthma attack in the last year (PR = 4.7; 95% CI 1.9 to 11.4)) and to a minimally exposed internal reference group (ever trouble with breathing (PR = 2.8; 95% CI 1.1 to 7.0) and work-related shortness of breath in the last year (PR = 7.5; 95% CI 1.1 to 52.9)). Lung function did not differ between groups. A positive relationship between exposure and FEV1 was found. Conclusion: The excess of respiratory symptoms in this retrospective cohort suggests that diacetyl production poses an occupational hazard. Limited historical exposure data did not support a quantitative individual diacetyl exposure–response relationship, but our findings suggest that preventive measures are prudent. ER -