RT Journal Article
SR Electronic
T1 Occupational exposure to asbestos and man-made vitreous fibres and risk of lung cancer: a multicentre case-control study in Europe
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 502
OP 508
DO 10.1136/oem.2006.027748
VO 64
IS 8
A1 Rafael Carel
A1 Ann C Olsson
A1 David Zaridze
A1 Neonila Szeszenia-Dabrowska
A1 Peter Rudnai
A1 Jolanta Lissowska
A1 Eleonora Fabianova
A1 Adrian Cassidy
A1 Dana Mates
A1 Vladimir Bencko
A1 Lenka Foretova
A1 Vladimir Janout
A1 Joelle Fevotte
A1 Tony Fletcher
A1 Andrea ’t Mannetje
A1 Paul Brennan
A1 Paolo Boffetta
YR 2007
UL http://oem.bmj.com/content/64/8/502.abstract
AB Objectives: To investigate the contribution of occupational exposure to asbestos and man-made vitreous fibres (MMVF) to lung cancer in high-risk populations in Europe. Methods: A multicentre case-control study was conducted in six Central and Eastern European countries and the UK, during the period 1998–2002. Comprehensive occupational and sociodemographic information was collected from 2205 newly diagnosed male lung cancer cases and 2305 frequency matched controls. Odds ratios (OR) of lung cancer were calculated after adjusting for other relevant occupational exposures and tobacco smoking. Results: The OR for asbestos exposure was 0.92 (95% CI 0.73 to 1.15) in Central and Eastern Europe and 1.85 (95% CI 1.07 to 3.21) in the UK. Similar ORs were found for exposure to amphibole asbestos. The OR for MMVF exposure was 1.23 (95% CI 0.88 to 1.71) with no evidence of heterogeneity by country. No synergistic effect either between asbestos and MMVF or between any of them and smoking was found. Conclusion: In this large community-based study occupational exposure to asbestos and MMVF does not appear to contribute to the lung cancer burden in men in Central and Eastern Europe. In contrast, in the UK the authors found an increased risk of lung cancer following exposure to asbestos. Differences in fibre type and circumstances of exposure may explain these results.