RT Journal Article
SR Electronic
T1 Fertility and exposure to solvents among families in the Agricultural Health Study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 469
OP 475
DO 10.1136/oem.2005.021337
VO 63
IS 7
A1 M Sallmén
A1 D D Baird
A1 J A Hoppin
A1 A Blair
A1 D P Sandler
YR 2006
UL http://oem.bmj.com/content/63/7/469.abstract
AB Background: Several studies have reported associations between solvent exposure and reduced female fertility, but the evidence is inconclusive for male fertility. Objectives: To investigate the impact of solvent exposure on subfertility among families of male licensed pesticide applicators in the Agricultural Health Study cohort. Methods: The couples enrolled between 1993 and 1997. Cross-sectional questionnaire information on work tasks was used to assess exposure to solvents. The data were limited to couples (wife aged less than 40 years) with an attempt at pregnancy in the last four years (n = 2112). Results: Twenty eight per cent of the couples were defined as subfertile (not conceiving a pregnancy after at least 12 months of unprotected intercourse, regardless of whether or not a pregnancy ultimately occurred). Adjusted subfertility odds ratios (OR) for exposure to solvents were calculated with logistic regression. Female (OR 1.42, 95% CI 1.15 to 1.75) and male exposure to solvents (OR 1.21 (95% CI 0.93 to 1.57) for monthly exposure and 1.40 (95% CI 0.97 to 2.03) for daily or weekly exposure) were associated with subfertility. In farming, spouses may share or exchange jobs. To account for potential dual exposure, variables for parental exposure (either parent exposed or both parents exposed) were also defined. Both were strongly associated with subfertility (OR 1.62 (95% CI 1.20 to 2.17) and OR 2.10 (95% CI 1.22 to 3.60), respectively). Conclusions: Solvents may impair fertility of either gender, though the evidence for female effects is stronger than for male effects.