TY - JOUR T1 - Occupational risk factors for nasopharyngeal cancer among female textile workers in Shanghai, China JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 39 LP - 44 DO - 10.1136/oem.2005.021709 VL - 63 IS - 1 AU - W Li AU - R M Ray AU - D L Gao AU - E D Fitzgibbons AU - N S Seixas AU - J E Camp AU - K J Wernli AU - G Astrakianakis AU - Z Feng AU - D B Thomas AU - H Checkoway Y1 - 2006/01/01 UR - http://oem.bmj.com/content/63/1/39.abstract N2 - Aims: To investigate whether occupational exposure to dusts and chemicals in the Chinese textile industry are associated with risk of nasopharyngeal cancer. Methods: Sixty seven nasopharyngeal carcinoma (NPC) cases identified during 1989–98 and a random sample (n = 3188) of women were included in a case cohort study nested in a cohort of 267 400 women textile workers in Shanghai, China. A complete occupational history of work in the textile industry was obtained for each woman. A job exposure matrix developed by experienced industrial hygienists was used to assess exposures to specific dusts and chemicals. Results: Risk of NPC is associated with cumulative exposure to cotton dust. The hazard ratio for women cumulatively exposed to >143.4 mg/m3 × years of cotton dust was 3.6 (95% CI 1.8 to 7.2) compared with unexposed women. Trends of increasing risk were also found with increasing duration of exposure to acids and caustics (p = 0.05), and with years worked in dyeing processes (p = 0.06). Women who worked at least 10 years in dyeing processes had a 3.6-fold excess risk of NPC (95% CI 1.0 to 12.1). Conclusions: Occupational exposure to cotton dust, acids, and caustics, and work in dyeing and printing jobs in the textile industry may have increased risk of NPC in this cohort. ER -