TY - JOUR T1 - Changing trends in US mesothelioma incidence JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 438 LP - 441 DO - 10.1136/oem.2003.010165 VL - 61 IS - 5 AU - H Weill AU - J M Hughes AU - A M Churg Y1 - 2004/05/01 UR - http://oem.bmj.com/content/61/5/438.abstract N2 - Aims: To report the temporal pattern and change in trend of mesothelioma incidence in the United States since 1973. Methods: The Surveillance, Epidemiology, and End Results (SEER) programme of the National Cancer Institute has since 1973 provided annual age adjusted incidence for mesothelioma in representative cancer registries dispersed throughout the USA. SEER data are analysed to describe the trend of male mesothelioma incidence in the USA. Results: The US male mesothelioma incidence data indicate that after two decades of increasing incidence, a likely decline has been observed since the early 1990s, when a highly significant change in the upward course occurred. Conclusions: Increasing male mesothelioma incidence for many years was undoubtedly the result of exposure to asbestos. The high mesothelioma risk was prominently influenced by exposure to amphibole asbestos (crocidolite and amosite), which reached its peak usage in the 1960s and thereafter declined. A differing pattern in some other countries (continuing rise in incidence) may be related to their greater and later amphibole use, particularly crocidolite. The known latency period for the development of this tumour provides biological plausibility for the recent decline in mesothelioma incidence in the USA. This favourable finding is contrary to a widespread fear that asbestos related health effects will show an inevitable increase in coming years, or even decades. ER -