TY - JOUR T1 - Genetic make up and external stimuli interact to cause lung disease JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 661 LP - 661 DO - 10.1136/oem.60.9.661 VL - 60 IS - 9 A2 - , Y1 - 2003/09/01 UR - http://oem.bmj.com/content/60/9/661.abstract N2 - A prospective epidemiological study in coal miners is the first to suggest that genetic background and environmental oxidative stimuli interact to influence development of pneumoconiosis.Tumour necrosis factor α (TNF) −308 genotype affected glutathione peroxidase (GSH-Px) and catalase activities in red blood cells. Genotypes with homozygous 22, heterozygous 12 alleles significantly … ER -