TY - JOUR T1 - Vibration perception thresholds in workers with long term exposure to lead JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 588 LP - 594 DO - 10.1136/oem.57.9.588 VL - 57 IS - 9 AU - Hung-Yi Chuang AU - Joel Schwartz AU - Song-Yen Tsai AU - Mei-Ling Ting Lee AU - Jung-Der Wang AU - Howard Hu Y1 - 2000/09/01 UR - http://oem.bmj.com/content/57/9/588.abstract N2 - OBJECTIVES To evaluate the impact of long term occupational exposure to lead on function of the peripheral nervous system as reflected by vibration perception threshold (VPT), measured with a portable vibrameter. METHODS 217 Workers in a lead battery factory were required to have an annual blood lead measurement during each of the 5 years preceding this study. All were invited to take the VPT test. A total of 206 workers were studied. The associations were analysed between VPTs and current blood lead concentration, mean concentration of blood lead over the past 5 years, maximum blood lead concentration during the past 5 years, index of cumulative blood lead (ICL), time weighted index of cumulative blood lead (TWICL), and percentage of lifespan spent at work in the plant, as well as the other potential confounders. Ordinary multiple regressions, generalised additive models, and hockey stick regression analyses were used to explore the potential existence of a threshold effect of blood lead variables on VPT. RESULTS VPT at a frequency of 220 Hz ranged from 6 to 100 (10-2 g, or 0.098 m/s2) with a mean (SD) of 19.8 (14.2) for the feet and from 4 to 43 with a mean (SD) of 10.2 (6.1) for the hands. The five variables of exposure to lead were all significantly correlated with VPT of the feet but not the hands. In multiple linear regression analyses, the mean of the blood lead concentrations and the TWICL were significantly associated with VPT of the feet. The relation between VPT of the feet and mean blood lead was shown to be a J shaped curve with a generalised additive model and local smoothing technique. In the hockey stick regression, evidence was found of a threshold effect at a mean blood lead concentration of 31 μg/dl. Above this threshold it was estimated that each increase of 1 μg/dl mean blood lead over 5 years would increase VPT of the feet by 0.29 (10-2 g) or 0.028 m/s2 (at a frequency of 220 Hz) with other potential confounders held constant. CONCLUSION This study suggests that measurement of vibration sensory threshold is a relatively effective tool for detecting lead neuropathy in field studies, and that lead might cause sensory neuropathy with an effect threshold corresponding to a 5 year mean blood lead concentration of 31 μg/dl. ER -