RT Journal Article
SR Electronic
T1 In vitro percutaneous penetration of methyl-parathion from a commercial formulation through the human skin.
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 524
OP 525
DO 10.1136/oem.54.7.524
VO 54
IS 7
A1 P Sartorelli
A1 C Aprea
A1 R Bussani
A1 M T Novelli
A1 D Orsi
A1 G Sciarra
YR 1997
UL http://oem.bmj.com/content/54/7/524.abstract
AB OBJECTIVE: To compare in vitro percutaneous absorption of methyl-parathion dissolved in an acetone vehicle and in the form of a commercial formulation. METHODS: Penetration through the human skin was measured in Franz diffusion cells with full thickness skin from a human cadaver as the membrane. The two tailed non-parametric Mann-Whitney U test was used to compare the cumulative diffusion of methyl-parathion in the receptor fluid of the cells at various time intervals. RESULTS: In vitro skin penetration of methyl-parathion was significantly higher with the commercial formulation. The percentage of the applied dose absorbed after 24 hours was 5.20% v 1.35%. The mean lag time was < 8 hours. CONCLUSION: Assessments of uptake and internal dose after exposure to pesticides should be based on the commercial products rather than active ingredients, because of the crucial role of the vehicle, as shown in this study.