PT  - JOURNAL ARTICLE
AU  - Enterline, P E
AU  - Day, R
AU  - Marsh, G M
TI  - Cancers related to exposure to arsenic at a copper smelter.
AID  - 10.1136/oem.52.1.28
DP  - 1995 Jan 01
TA  - Occupational and Environmental Medicine
PG  - 28--32
VI  - 52
IP  - 1
4099  - http://oem.bmj.com/content/52/1/28.short
4100  - http://oem.bmj.com/content/52/1/28.full
SO  - Occup Environ Med1995 Jan 01; 52
AB  - OBJECTIVE--This is an update of an earlier study on the relation between exposure to arsenic in air and deaths from respiratory cancer. The purpose was to verify earlier findings of a supralinear dose response relation and to examine relations with other cancers, particularly those reported in studies on drinking water. METHODS--An earlier study of 2802 men who worked at a copper smelter for a year or more during the period 1940-64 and who were followed up for deaths during the period 1941-76 was updated until 1986. Estimates of exposure for the period 1977-1984 were added. RESULTS AND CONCLUSIONS--The additional follow up confirms the earlier finding that at low doses the increments in death rates for respiratory cancer for a given increment in dose are greater than at high doses. The additional follow up also shows significant increases in cancer of the large intestine and bone, and SMRs > 150 for cancer of the buccal cavity and pharynx, rectal cancer, and kidney cancer. There was a positive relation between exposure to arsenic in air and kidney and bone cancer, but none for the other cancers, except respiratory.