PT  - JOURNAL ARTICLE
AU  - M F Ferreira Júnior
AU  - S Tas
AU  - M dell'Omo
AU  - G Goormans
AU  - J P Buchet
AU  - R Lauwerys
TI  - Determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin in workers exposed to polycyclic aromatic hydrocarbons.
AID  - 10.1136/oem.51.7.451
DP  - 1994 Jul 01
TA  - Occupational and Environmental Medicine
PG  - 451--455
VI  - 51
IP  - 7
4099  - http://oem.bmj.com/content/51/7/451.short
4100  - http://oem.bmj.com/content/51/7/451.full
SO  - Occup Environ Med1994 Jul 01; 51
AB  - OBJECTIVE--The aim was to assess the determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin (BaPDE-Hb) in workers exposed to polycyclic aromatic hydrocarbons (PAHs). METHODS--This was a study of the correlations between the concentrations of PAHs in air, 1-hydroxyprene in urine, and BaPDE-Hb adduct concentration in the blood in 206 men working in steel foundries and one graphite electrode producing plant, taking into consideration confounding factors such as smoking and dietary habits. RESULTS--BaPDE-Hb adduct concentration was correlated (r = 0.26; p = 0.0002) with the airborne PAH concentration and was influenced by tobacco consumption but not by dietary habits. Benzo(a)-pyrene concentration in air, 1-hydroxypyrene concentration in urine, and duration of exposure to PAHs were not associated with the adduct concentration. CONCLUSION--Although environmental exposure to PAHs was statistically associated with BaPDE-Hb adduct concentration, differences between individual subjects in the metabolism of benzo(a)pyrene probably play an important part in determining the amount of BaPDE-Hb adducts formed.