TY - JOUR T1 - Effects of methyl isocyanate on rat brain cells in culture. JF - British Journal of Industrial Medicine JO - Br J Ind Med SP - 596 LP - 601 DO - 10.1136/oem.47.9.596 VL - 47 IS - 9 AU - D Anderson AU - S Goyle AU - B J Phillips AU - A Tee AU - L Beech AU - W H Butler Y1 - 1990/09/01 UR - http://oem.bmj.com/content/47/9/596.abstract N2 - Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to brain cells and the response was dose related. The observations were supported by light and electron microscopy. ER -