RT Journal Article
SR Electronic
T1 Effects of methyl isocyanate on rat brain cells in culture.
JF British Journal of Industrial Medicine
JO Br J Ind Med
FD BMJ Publishing Group Ltd
SP 596
OP 601
DO 10.1136/oem.47.9.596
VO 47
IS 9
A1 D Anderson
A1 S Goyle
A1 B J Phillips
A1 A Tee
A1 L Beech
A1 W H Butler
YR 1990
UL http://oem.bmj.com/content/47/9/596.abstract
AB Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to brain cells and the response was dose related. The observations were supported by light and electron microscopy.