RT Journal Article
SR Electronic
T1 Excretion kinetics of urinary metabolites in a patient addicted to trichloroethylene
JF British Journal of Industrial Medicine
JO Br J Ind Med
FD BMJ Publishing Group Ltd
SP 203
OP 206
DO 10.1136/oem.28.2.203
VO 28
IS 2
A1 Ikeda, Masayuki
A1 Ohtsuji, Hatsue
A1 Kawai, Hitoshi
A1 Kuniyoshi, Masichi
YR 1971
UL http://oem.bmj.com/content/28/2/203.abstract
AB Ikeda, M., Ohtsuji, H., Kawai, H., and Kuniyoshi, M. (1971).Brit. J. industr. Med.,28, 203-206. Excretion kinetics of urinary metabolites in a patient addicted to trichlorethylene. A male Japanese subject, single, aged 38, who worked at a workshop washing metal parts with trichloroethylene, was admitted to our clinic due to addiction to the solvent. Analyses of urine revealed the presence of up to 160 μg/ml of trichloro-compounds (mostly trichloroacetic acid) which gradually disappeared in three weeks as the psychotic symptoms cleared up. The excretion half-lives of trichloroethylene metabolites for the initial rapid phase (succeeding slow phase in parentheses) were 5·8 (49·7) hours for trichloroethanol, 22·5 (72·6) hours for trichloroacetic acid, and 7·5 (72·6) hours for total trichloro-compounds.