RT Journal Article
SR Electronic
T1 Effects of Sodium and Hydrogen Flourides on the Metabolism of Flourine, Calcium, and Phosphorus in Rats
JF British Journal of Industrial Medicine
JO Br J Ind Med
FD BMJ Publishing Group Ltd
SP 131
OP 135
DO 10.1136/oem.25.2.131
VO 25
IS 2
A1 Macuch, P.
A1 Kortus, J.
A1 Balazova, G.
A1 Mayer, J.
YR 1968
UL http://oem.bmj.com/content/25/2/131.abstract
AB Rats given 4 mg. fluoride/kg./day for eight days excreted more calcium and phosphorus and retained less than the controls. In bone ash from rats given different fluoride doses for 40 days the calcium and phosphorus were maximal after a total dose of about 250 μg. fluoride/rat, but fell to subnormal levels after higher doses. The calcium and phosphorus levels in bone ash from rats given 750 μg. fluoride/day fell with the duration of treatment. Rats exposed to 9·4-11·7 μg. hydrogen fluoride/litre air absorbed fluoride rapidly, as shown by increased urinary excretion, by changes in the enamel of the teeth, and by rising fluoride levels in the teeth and bones. Radiological examination, however, showed no gross changes. Urinary excretion increased with exposure time.