eLetters

74 e-Letters

published between 2000 and 2003

  • Amyotrophic lateral sclerosis and occupational exposure to 2,4-dichlorophenoxyacetic
    Michal Freedman

    Editor

    Burns et al.[1] report a significant excess of deaths due to amyotrophic lateral sclerosis (ALS) in a cohort of Dow employees potentially exposed to the herbicide 2,4-Dichlorophenoxyacetic (2,4-D), but then argue against the plausibility of a causal association, concluding that the association "is not consistent with previous human or animal studies".

    This conclusion and the authors' characterisatio...

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  • Cancer risk from occupational acrylamide exposure
    Gary M Marsh

    Editor,

    Granath and colleagues take issue with our update of a cohort of acrylamide (AMD) workers from three U.S. plants[1] claiming that "it exemplifies the shortcomings of studies of this type to detect moderate influences of specific causative factors on cancer mortality or incidence." To support their contention that we overlooked a small but "unacceptable" increase in cancer risk, they performed a crude q...

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  • Cancer risk from occupational acrylamide exposure
    Margareta Tornqvist

    Editor,

    Recently the results of a comprehensive epidemiological follow up study of cancer mortality in cohorts with occupational exposure to acrylamide was published.[1] With the exception of a weak significance for a raised incidence of pancreas cancer the study arrived by and large at the conclusion that there is "little evidence for a causal relationship between exposure to acrylamide and mortality from any c...

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  • Dose-response relationship between acrylamide and pancreatic cancer
    MR Schulz

    Editor,

    In their 1999 study of workers exposed to acrylamide, Marsh et al conducted an SMR analysis and fit several relative risk regression models to the data.[1] In each analysis, they found risk of pancreatic cancer elevated by about twofold for workers in the highest cumulative exposure group, but risk of pancreatic cancer did not increase monotonically with cumulative exposure in any of their analyses. Dur...

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  • Glutaraldehyde induced asthma in endoscopy nursing staff
    Wasif Anees

    Editor

    We read with interest the paper on glutaraldehyde and symptoms in endoscopy nursing staff.[1] It is reported that there was an absence of objective evidence of the physiological changes associated with asthma. Peak expiratory flow (PEF) records from 17 cases were analysed by the Oasys 2 computer program, and three of these had Oasys-2 Scores >2.5. These cases were felt not to show asthma because PEF d...

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  • Personal exposure of children to nitrogen dioxide
    L A Palin

    Editor,

    We read with interest a recently published study on personal exposure of asthmatic children to nitrogen dioxide (NO2), relative to concentrations in outdoor air.[1] In their results, authors didn't find: 1. "…significant correlation… between each child's weekly mean personal exposures and mean outdoor concentrations for the corresponding periods"; 2. "…marked evidence of seasonality" on personal exposure...

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  • Guidelines on good publication practice
    CJ Kalman

    Editor,
    I was interested to read the excellent COPE Report Paper[1] and note Occupational and Environmental Medicine's intention to follow these guidelines.

    In particular, from the occupational health point of view, I welcome the inclusion of involvement of the study participants in consideration and agreement of the research protocol, though I am a little sad that the COPE Committee...

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  • Bullying in hospitals
    TS Koh

    Editor

    As victims of bullying and proponents of emotional intelligence in the health profession we read with interest your article on workplace bullying.[1]

    Kavimaki et al[1] did not mentioned whether the responses were anonymous. Identified responses may underestimate the incidence of bullying in the cohort. Given that previous studies (mentioned by the authors in the discussion) have shown a consid...

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  • Symptoms among endoscopy nursing staff
    Eugene R Waclawski

    The recent article by Vyas, et al.[1] raises some concerns to which I would be grateful if they could respond.

    1) In the abstract one of the objectives is stated as finding the nature and incidence of symptoms experienced by a large sample of hospital endoscopy nurses. The study design is cross-sectional and used an adapted version of the MRC questionnaire for respiratory symptoms. This study design normally re...

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  • Author's reply to occupational exposures and pancreatic cancer: a meta-analysis
    Anneli Ojajarvi

    Editor

    We thank Dr. Seilkop for his comment and have, in essence, not much to add to it. The study by Shannon et al.[1] had obviously been overlooked and the study by Arena et al.[2] was published after our deadline for the inclusion of studies.

    Dr. Seilkop´s Table has errors for the study by Andersson et al.[3] The number of pacreatic cancer deaths should be 2; relative risk should be 1.2; and 95% conf...

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