eLetters

33 e-Letters

published between 2010 and 2013

  • 4-Chloro-ortho-toluidine is not present in cigarette smoke
    Elmar Richter

    Within the Introduction the authors wrongly state that 4-chloro-ortho -toluidine is present in cigarette smoke. Whereas ortho-toluidine has been repeatedly reported to be present in cigarette smoke, this has never been reported for 4-chloro-ortho-toluidine. ortho-Toluidine has also been implicated in bladder cancer in the rubber industry (Baan et al. Lancet Oncol. 9:322-323, 2008) and this was corroborated by results of a...

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  • Response to Boers et al: request for additional results on cardiovascular disease
    Olivier Humblet

    We read with great interest the recent publication by Boers et al (2010), in which they presented updated mortality results from an occupational cohort of Dutch chlorophenoxy herbicide manufacturing workers. The previous follow-up from this cohort (Hooiveld et al, 1998) reported a statistically significant dose-related increase in mortality from ischemic heart disease (IHD) with increasing levels of modeled TCDD exposur...

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  • Effects of phenoxy acid herbicides
    Heikki Savolainen

    Dear Editor,

    This carefully conducted study (1) points at the kidney as a potential target of toxicity of phenoxy acids in a chronic occupational exposure.

    This is biologically plausible as the phenoxy acids are inhibitors of chloride channels in renal tubular cells (2) which leads to alterations in the excretion of urinary electrolytes (3).

    Thus, it is entirely possible that the chronic dysfun...

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