229 e-Letters

  • Observational Studies - Workforce Perspective?
    Christopher J Kalman

    The publication of an editorial(1) and opposing commentaries(2,3) underlines the profile OEM believes should be given to debate of the proposal for observational epidemiologic studies and their protocols to be registered in advance(4). I would however express my surprise that none of these 3 offerings make mention of the workforce perspective in their analyses of the issues. The editorial itself(1) and the commentary o...

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  • RE: The ghost of methods past: exposure assessment versus job-exposure matrix studies
    Parveen Bhatti

    Dr. Burstyn, in his commentary (1), underscores the critical importance of using the best exposure assessment methods possible to minimize misclassification. We agree about the value of expert formulated models for systematically and transparently documenting exposure assessment1, but caution that many existing studies may not be readily adapted to such model building. For such studies, the best alternative exposure ass...

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  • Re:Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study
    Pierluigi Cocco
    We thank Dr Triebig for his interesting comments on our article “Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study�.1,2 Epidemiological evidence is growing about the various etiological factors of specific lymphoma subtypes, and perhaps the different mechanisms involved.3 In our paper, we referred to previous reports suggesting an interaction o...
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  • Long-term carcinogenesis bioassays in animals are poor predictors of cancer risk to humans
    Joseph Manuppello

    In his letter, Predicting chemicals causing cancer in animals as human carcinogens (Occup Environ Med 2010;67:720), Huff surprisingly finds opportunity to promote long-term carcinogenesis bioassays using animals in response to an editorial by Suarthana et al (Occup Environ Med 2009;66:713e14), Predicting occupational diseases. In their editorial, Suarthana et al generalize from the development of diagnostic models to pred...

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  • Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study
    Gerhard Triebig

    Considering the temporal association between exposure to benzene and the later development of leukaemia it is questionable if this phenomena is also true for NHL.1 From several independent epidemiologic studies with consistent findings it can be concluded, that 10 to 15 years after exposure to benzene has been stopped, the risk of leukaemia is significantly less or even absent.2,3,4

    Assuming that the underlying...

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  • 4-Chloro-ortho-toluidine is not present in cigarette smoke
    Elmar Richter

    Within the Introduction the authors wrongly state that 4-chloro-ortho -toluidine is present in cigarette smoke. Whereas ortho-toluidine has been repeatedly reported to be present in cigarette smoke, this has never been reported for 4-chloro-ortho-toluidine. ortho-Toluidine has also been implicated in bladder cancer in the rubber industry (Baan et al. Lancet Oncol. 9:322-323, 2008) and this was corroborated by results of a...

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  • Response to Boers et al: request for additional results on cardiovascular disease
    Olivier Humblet

    We read with great interest the recent publication by Boers et al (2010), in which they presented updated mortality results from an occupational cohort of Dutch chlorophenoxy herbicide manufacturing workers. The previous follow-up from this cohort (Hooiveld et al, 1998) reported a statistically significant dose-related increase in mortality from ischemic heart disease (IHD) with increasing levels of modeled TCDD exposur...

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  • Effects of phenoxy acid herbicides
    Heikki Savolainen

    Dear Editor,

    This carefully conducted study (1) points at the kidney as a potential target of toxicity of phenoxy acids in a chronic occupational exposure.

    This is biologically plausible as the phenoxy acids are inhibitors of chloride channels in renal tubular cells (2) which leads to alterations in the excretion of urinary electrolytes (3).

    Thus, it is entirely possible that the chronic dysfun...

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  • Consider Hours Worked
    James L Weeks

    To the Editor:

    Laney, et al. [1] provide important and compelling insight to potential causes of the unexpected occurrence of progressive massive fibrosis among underground coal miners in some areas of the U.S. Based on the occurrence of “r” opacities in these films, exposure to quartz is the likely cause. This conclusion is supported by an exposure assessment that shows elevated exposure to quartz dust in area...

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  • Mesothelioma Risk From Chrysotile
    John Hodgson

    We welcome the appearance of this new analysis of asbestos related mortality which constitutes an important addition to the available evidence. We note that the lung cancer risk from this data highlighted by the authors and based on their internal analyses gives an identical risk factor to the one suggested as the 'best estimate' in our earlier meta- analysis (1): a relative risk of 1.102 per 100 f/ml.yr translates almost...

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