232 e-Letters

  • A dose-response for asbestos
    John H. Lange

    The article by Clin et al. (1) provides additional information for a dose-response relationship with asbestos and cancer. Information where a response curve changes effect as observed from background is critical in establishing a safe exposure limit (threshold -exposure/concentration- dose). Some investigators have reported this threshold is around 25 fiber/ml-years (2); although for some members of an exposed group thi...

    Show More
  • Renal effects of cadmium exposure
    Heikki Savolainen

    Dear Editor,

    I have read with the greatest interest the convincing study on the dose-response of cadmium ions in kidneys (1). Cadmium compounds also harm the proteoglycan metabolism (2), and by using the urinary proteoglycan excretion as an indicator of cadmium effects the threshold would be at 5 microg/g creatinine (3). This agrees very well with the threshold found in the current investigation.

    1 Cha...

    Show More
  • Response to: Exposure to occupational noise and cardiovascular disease in the United States: the National Health and Nutrition Examination Survey 1999-2004. Gan et al. 68:183-190 doi:10.1136/oem.2010.055269
    Karlene S Lavelle

    Gan et al, 2011 [1] concluded that long-term, occupational noise exposure was associated with increased prevalence of coronary heart disease (CHD), for which the authors report a clear exposure-response relationship that was particularly strong for participants aged < 50 years, men and current smokers. We do not believe the results support these conclusions, particularly in light of notable study limitations.

    Show More
  • Observational Studies - Workforce Perspective?
    Christopher J Kalman

    The publication of an editorial(1) and opposing commentaries(2,3) underlines the profile OEM believes should be given to debate of the proposal for observational epidemiologic studies and their protocols to be registered in advance(4). I would however express my surprise that none of these 3 offerings make mention of the workforce perspective in their analyses of the issues. The editorial itself(1) and the commentary o...

    Show More
  • RE: The ghost of methods past: exposure assessment versus job-exposure matrix studies
    Parveen Bhatti

    Dr. Burstyn, in his commentary (1), underscores the critical importance of using the best exposure assessment methods possible to minimize misclassification. We agree about the value of expert formulated models for systematically and transparently documenting exposure assessment1, but caution that many existing studies may not be readily adapted to such model building. For such studies, the best alternative exposure ass...

    Show More
  • Re:Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study
    Pierluigi Cocco
    We thank Dr Triebig for his interesting comments on our article “Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study�.1,2 Epidemiological evidence is growing about the various etiological factors of specific lymphoma subtypes, and perhaps the different mechanisms involved.3 In our paper, we referred to previous reports suggesting an interaction o...
    Show More
  • Long-term carcinogenesis bioassays in animals are poor predictors of cancer risk to humans
    Joseph Manuppello

    In his letter, Predicting chemicals causing cancer in animals as human carcinogens (Occup Environ Med 2010;67:720), Huff surprisingly finds opportunity to promote long-term carcinogenesis bioassays using animals in response to an editorial by Suarthana et al (Occup Environ Med 2009;66:713e14), Predicting occupational diseases. In their editorial, Suarthana et al generalize from the development of diagnostic models to pred...

    Show More
  • Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study
    Gerhard Triebig

    Considering the temporal association between exposure to benzene and the later development of leukaemia it is questionable if this phenomena is also true for NHL.1 From several independent epidemiologic studies with consistent findings it can be concluded, that 10 to 15 years after exposure to benzene has been stopped, the risk of leukaemia is significantly less or even absent.2,3,4

    Assuming that the underlying...

    Show More
  • 4-Chloro-ortho-toluidine is not present in cigarette smoke
    Elmar Richter

    Within the Introduction the authors wrongly state that 4-chloro-ortho -toluidine is present in cigarette smoke. Whereas ortho-toluidine has been repeatedly reported to be present in cigarette smoke, this has never been reported for 4-chloro-ortho-toluidine. ortho-Toluidine has also been implicated in bladder cancer in the rubber industry (Baan et al. Lancet Oncol. 9:322-323, 2008) and this was corroborated by results of a...

    Show More
  • Response to Boers et al: request for additional results on cardiovascular disease
    Olivier Humblet

    We read with great interest the recent publication by Boers et al (2010), in which they presented updated mortality results from an occupational cohort of Dutch chlorophenoxy herbicide manufacturing workers. The previous follow-up from this cohort (Hooiveld et al, 1998) reported a statistically significant dose-related increase in mortality from ischemic heart disease (IHD) with increasing levels of modeled TCDD exposur...

    Show More