You are here

  • Home
  • Online First
  • Dupuytren’s disease and occupational mechanical exposures: a systematic review and meta-analysis

Article Text

Article menu
Download PDFPDF
Systematic review
Dupuytren’s disease and occupational mechanical exposures: a systematic review and meta-analysis
  1. Alexander Jahn1,
  2. Johan Hviid Andersen2,3,
  3. Alexis Descatha4,5,
  4. Annett Dalbøge1,3
  1. 1Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus N, Denmark
  2. 2Department of Occupational Medicine - University Research Clinic, Danish Ramazzini Centre, Regional Hospital Goedstrup, Herning, Denmark
  3. 3Aarhus University Department of Clinical Medicine, Aarhus, Denmark
  4. 4Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC, Angers, France
  5. 5Department of Occupational Medicine, Epidemiology and Prevention, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA
  1. Correspondence to Alexander Jahn; alexjn{at}rm.dk

Abstract

The risk of developing Dupuytren’s disease among workers exposed to occupational mechanical exposures has been reported in few systematic reviews, mainly related to vibration. Expanding the investigation to all occupational mechanical exposures is essential for advancing scientific knowledge, health policies and improving workplace safety. The aim of this systematic review and meta-analysis was to study the association between occupational mechanical exposures and Dupuytren’s disease.

We conducted a systematic review and meta-analysis using guidelines stated by PRISMA. The systematic literature search was performed in Medline, EMBASE, CINAHL, Cochrane Library and Web of Science databases in April 2023. Inclusion criteria were conducted using the PECOS. Two independent authors conducted the literature screening, data extraction and risk of bias assessment. In the meta-analyses, data was pooled using random-effects models and stratified by the risk of bias and study design. The level of evidence was evaluated using GRADE.

The literature search identified 563 unique articles and 15 were deemed eligible for inclusion, categorised into hand-transmitted vibration, lifting/carrying loads and combined mechanical exposures. Exposure to hand-transmitted vibration showed an OR of 2.0 (95% CI 1.5 to 2.7, I2=64%), lifting/carrying loads had an OR of 1.5 (95% CI 1.1 to 2.0, I2=77%) and combined mechanical exposures had an OR of 2.1 (95% CI 1.4 to 3.1, I2=94%). When grading the level of evidence, we found moderate evidence for hand-transmitted vibration, while low evidence was found for lifting/carrying loads and combined mechanical exposures.

We found an association between hand-transmitted vibration, lifting/carrying loads and combined mechanical exposures. The level of evidence was considered moderate for hand-transmitted vibration and low for lifting/carrying loads and combined mechanical exposures.

  • Ergonomics
  • Workload
  • Epidemiology
  • Occupational Health
  • Meta-analysis

Data availability statement

Data are available upon reasonable request. All data are available from the corresponding author upon reasonable request.

https://doi.org/10.1136/oemed-2024-109649

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Data availability statement

    Data are available upon reasonable request. All data are available from the corresponding author upon reasonable request.

    View Full Text

    Footnotes

    • Contributors All authors contributed to the manuscript, ensured the quality, revised the manuscript, and read and approved the final version. ADa and JHA wrote the initial application and acquired funding. AJ, ADa and JHA conducted the literature screening and risk of bias assessments. AJ was responsible for drafting the manuscript and conducting the analyses—and is also the guarantor. ADe read and revised the manuscript and all authors approved the final manuscript.

    • Funding The systematic review and meta-analysis was requested by The Labour Market Insurance and the Occupational Diseases Committee in Denmark in order to re-evaluate the existing guidelines of the exposure requirements in relation to compensation. The Danish Work Environment Fund granted the conduction of the systematic review and meta-analysis (project number: 30-2022-09 20225100752). The systematic review was conducted independently of the fund, and we were not involved in the re-evaluating of the existing guidelines of the exposure requirements.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.