Objectives This study aims to explore the prevalence and clinical features of pulmonary hypertension (PH) in patients with progressive massive fibrosis (PMF) and its correlation with large opacities on CT scans.
Methods This retrospective study collected 235 patients with PMF, and 199 were eligible for analysis. The probability of PH development was estimated based on tricuspid regurgitation velocity measured by echocardiogram. The size and the location of large opacities on chest CT were recorded. Potential risk factors for PH secondary to PMF were analysed using regression analysis.
Results The prevalence of a high or intermediate probability of PH was 39.7% in patients with PMF. Type C of large opacities (OR 6.99, 95% CI 2.34 to 23.00, p<0.001) and central type of the large opacities (OR 8.12, 95% CI 2.89 to 24.71, p<0.001) were identified as the risk factors for PH secondary to PMF. Over a median follow-up of 32.8 months, the survival rate was 73.3% in the PH group, significantly lower than that in the non-PH group (96.6%, p<0.001).
Conclusions Over one-third of patients with PMF developed PH. The increased size and the central distribution of large opacities were identified as the risk factors.
- Risk assessment
- Lung Diseases, Interstitial
- Respiratory System
Data availability statement
Data are available upon reasonable request.
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Contributors SY performed all data collection, analysed and wrote the manuscript. YiW and YF were responsible for data analysing. RM and YuW were responsible for recruiting the patients. QY contributed as primary investigator and was responsible for designing the study, recruiting the patients and writing the manuscript. All authors read and approved the final manuscript.
Funding The work was supported by National Natural Science Foundation of China (81970061), Application of Clinical Characteristics in Capital (Z181100001718118) and Strategic consulting project of Chinese Academy of Engineering (2021-JJZD-10).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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