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Original research
Pulmonary hypertension in patients with pneumoconiosis with progressive massive fibrosis
  1. Shiwen Yu,
  2. Yiran Wang,
  3. Yali Fan,
  4. Ruimin Ma,
  5. Yuanying Wang,
  6. Qiao Ye
  1. Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital Capital Medical University, Beijing, China
  1. Correspondence to Professor Qiao Ye, Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital Capital Medical University, Beijing, Beijing, China; yeqiao_chaoyang{at}sina.com

Abstract

Objectives This study aims to explore the prevalence and clinical features of pulmonary hypertension (PH) in patients with progressive massive fibrosis (PMF) and its correlation with large opacities on CT scans.

Methods This retrospective study collected 235 patients with PMF, and 199 were eligible for analysis. The probability of PH development was estimated based on tricuspid regurgitation velocity measured by echocardiogram. The size and the location of large opacities on chest CT were recorded. Potential risk factors for PH secondary to PMF were analysed using regression analysis.

Results The prevalence of a high or intermediate probability of PH was 39.7% in patients with PMF. Type C of large opacities (OR 6.99, 95% CI 2.34 to 23.00, p<0.001) and central type of the large opacities (OR 8.12, 95% CI 2.89 to 24.71, p<0.001) were identified as the risk factors for PH secondary to PMF. Over a median follow-up of 32.8 months, the survival rate was 73.3% in the PH group, significantly lower than that in the non-PH group (96.6%, p<0.001).

Conclusions Over one-third of patients with PMF developed PH. The increased size and the central distribution of large opacities were identified as the risk factors.

  • Silicosis
  • Risk assessment
  • Lung Diseases, Interstitial
  • Respiratory System

Data availability statement

Data are available upon reasonable request.

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Data availability statement

Data are available upon reasonable request.

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Footnotes

  • Contributors SY performed all data collection, analysed and wrote the manuscript. YiW and YF were responsible for data analysing. RM and YuW were responsible for recruiting the patients. QY contributed as primary investigator and was responsible for designing the study, recruiting the patients and writing the manuscript. All authors read and approved the final manuscript.

  • Funding The work was supported by National Natural Science Foundation of China (81970061), Application of Clinical Characteristics in Capital (Z181100001718118) and Strategic consulting project of Chinese Academy of Engineering (2021-JJZD-10).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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