Objectives Synthesis of melatonin follows a circadian cycle, with high melatonin levels during the night and low levels during the day. Light exposure at night has been hypothesised as one of potential mechanisms of breast carcinogenesis in the night shift workers through inhibition of melatonin synthesis. The aim of the study was to examine a number of determinants for night shift work in relation to 6-sulfatoxymelatonin (MT6s), primary melatonin metabolite.
Methods The cross-sectional study included 354 nurses and midwives (aged 40–60 years) currently working on rotating night shifts and 370 working days only. Data from questionnaires and 1-week diaries were used to characterise current job and total occupational history. Associations between rotating night shift work characteristics and MT6s (creatinine adjusted) in spot morning urine were tested in multiple linear regression models.
Results No significant differences were found for MT6s concentrations between women currently working on rotating night shifts and those working only day shifts (means 47.2 vs 45.7 ng/mg Cr, respectively). The adjusted means among rotating night shift nurses and midwives varied depending on the department of employment, from 35.1 ng/mg Cr in neonatology to 68.2 ng/mg Cr in the orthopaedics department. Women working eight or more night shifts per month had significantly lower MT6s levels than those having fewer night shifts per month (37.9 vs 47.4 ng/mg Cr, respectively). Total night shift work history was not associated with MT6s.
Conclusions The results of this study indicate that working eight or more night shifts per month may disrupt the synthesis of melatonin.
- Shift work
- circadian rhythms
- healthcare workers
- retrospective exposure assessment
- mortality studies
- longitudinal studies
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Funding This project is supported by a grant from the Polish-Norwegian Research Fund (PNRF 243-AI-1/07).
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by ethical institutional review board at the Nofer Institute of Occupational Medicine.
Provenance and peer review Not commissioned; externally peer reviewed.
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