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GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort
  1. Chris Carlsten1,
  2. Anne Dybuncio1,
  3. Allan Becker2,
  4. Moira Chan-Yeung1,
  5. Michael Brauer1
  1. 1Department of Medicine, University of British Columbia, Vancouver, Canada
  2. 2Department of Pediatrics, University of Manitoba, Winnipeg, Canada
  1. Correspondence to Dr Chris Carlsten, Vancouver General Hospital, 2775 Laurel Street, 7th Floor (The Lung Center), Vancouver, BC V5Z 1M9, Canada; chris.carlsten{at}

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We recently reported1 on the risk of incident asthma associated with traffic-related air pollution in a high-risk birth cohort in Vancouver, British Columbia. We have now examined the effect of two common polymorphisms in the glutathione-s-transferase P1 (GSTP1) gene that is known to metabolise oxidative species and which has been shown previously to modify risk of allergic disease associated with nitrogen dioxide (NO2) exposure.2

At 7 years of age, 173 children were assessed for asthma by paediatric allergists and peripheral blood was obtained from these children and their parents. DNA was genotyped by the Illumina BeadArray system (Illumina, San Diego, California, USA) following the …

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  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the University of British Columbia Research Ethics Board.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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