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Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France
  1. Martine Hours (martine.hours{at}
  1. Universite de Lyon, France
    1. Marlene Bernard
    1. Universite de Lyon, France
      1. Marie T Arslan
      1. Universite de Lyon, France
        1. Lucile Montestrucq
        1. Universite de Lyon, France
          1. Lesley Richardson
          1. Universite de Montreal, Canada
            1. Isabelle Deltour
            1. Institute of Cancer Epidemiology, Denmark
              1. Elisabeth Cardis
              1. Centre for Research in Environmental Epidemiology, Spain


                Objectives: To investigate possible associations between risk of acoustic neuroma and exposure to loud noise in leisure and occupational settings.

                Methods: A case-control study was conducted in France within the international INTERPHONE study. The cases were the 108 subjects diagnosed with acoustic neuroma between June 1st 2000 and August 31st 2003. Two controls per case were selected from the electoral rolls and individually matched for gender, age (± 5 years) and area (local authority district) of residence at the time of the case diagnosis. Multivariate analyses were conducted using conditional logistic regression. Adjustment was made for socio-economic status.

                Results: Acoustic neuroma was found to be associated with loud noise exposure [Odds-Ratio (OR) = 2.55; 95% Confidence Interval (CI) = 1.35-4.82], both in leisure settings, particularly when listening to loud music [OR = 3.88; 95% CI = 1.48-10.17] and at work [OR = 2.26; 95% CI = 1.08-4.72]. This risk increased with exposure duration (> 6 years leisure exposure: OR = 3.15; 95% CI = 1.07-9.24). Risk varied according to the type of noise (continuous or explosive, versus intermittent).

                Conclusion: The present results agree with other recent reports implicating loud noise in the risk of acoustic neuroma.

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