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Abstracts
Carcinogens/Cancer
O-57 Occupational exposure to endocrine disruptors and colorectal cancer risk in two Canadian cohorts
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  1. Laura Pelland-St-Pierre1,
  2. Marc-André Verner2,
  3. Vikki Ho3
  1. 1Department of Social and Preventive Medicine, School of Public Health (ESPUM), Université de Montréal, Montréal, Québec, Canada; Centre de recherche en santé publique (CReSP), Université de Montréal and CIUSSS Centre-Sud, Montréal, Québec, Canada
  2. 2Department of Occupational and Environmental Health, School of Public Health (ESPUM), Université de Montréal, Montréal, Québec, Canada
  3. 3Department of Social and Preventive Medicine, School of Public Health (ESPUM), Université de Montréal, Montréal, Québec, Canada

Abstract

Introduction Sex hormones have been implicated in the etiology of colorectal cancer. Endocrine disruptors (EDCs) are compounds that can interfere with sex hormone signalling and cause adverse health effects, including cancer. Exposure to EDCs is ubiquitous, but exposure in some workplaces occurs at much higher levels than in the general population.

Objective To determine whether occupational exposure to EDCs is associated with colorectal cancer risk.

Material and Methods A case-cohort study was nested in the Alberta’s Tomorrow Project (ATP) and in the Ontario Health Study (OHS). Incident cases of colorectal cancer were identified (NATP=202, NOHS=605); a sub-cohort of 3,464 participants was selected at baseline (NATP=565, NOHS=2,899). Occupational exposure to 17 EDCs was estimated via linkage to CANJEM, a job-exposure matrix, for participants’ longest-held job. Specifically, CANJEM provides a frequency-weighted intensity metric of exposure and it was used to categorize participants into never exposed, exposed and substantially exposed to each individual EDC. Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for colorectal cancer associated with occupational exposure to EDCs while controlling for confounders identified using a directed acyclic graph.

Results In ATP, exposure to arsenic (OR=2.86, 95%CI: 1.06–7.63), copper (OR=0.53, 95%CI: 0.29–0.92), lead (OR=0.58, 95%CI: 0.34–0.97) and substantial exposure to arsenic (OR=2.87, 95%CI: 1.01–1.80), phenol (OR=0.25, 95%CI: 0.08–0.61), and trichloroethylene (OR=0.45, 95%CI: 0.21–0.90) were associated with colorectal cancer. In OHS, exposure to polychlorinated biphenyls (OR=3.95, 95%CI: 1.82–8.55), styrene (OR=0.47, 95%CI: 0.26–0.79), and substantial exposure to aluminum (OR=1.32, 95%CI: 1.03–1.68), cadmium (OR=0.59, 95%CI: 0.38–0.87), lead (OR=1.29, 95%CI: 1.03–1.60), phthalates (OR=0.52, 95%CI: 0.25–0.96), and trichloroethylene (OR=1.43, 95%CI: 1.08–1.88) were associated with colorectal cancer.

Conclusion Of the 17 EDCs, five were associated with an increased risk, and seven with a decreased colorectal cancer risk; however, none of the associations were consistent between the two cohorts.

https://doi.org/10.1136/OEM-2023-EPICOH.200

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