Information on where occupational exposures to dangerous substances occur, how many workers are exposed, the levels of exposure, and the uptake of control measures and their effectiveness are crucial for the development and monitoring of effective interventions and exposure prevention in the workplace. The feasibility of establishing an Occupational Exposure-Control Intelligence System (OccECIS) for use in Great Britain was assessed. A scoping exercise mapped existing information of exposure tools and databases. The information sources were expanded further by input from an International Expert Advisory Committee (EAC) established to support the project in all aspects and analysed for their basic characteristics and relevance to the system. The outputs of the analysis were used together with inputs from the EAC to establish the basic conceptual framework underlying the system. This framework was converted to a set of theoretical questions relevant for the systems outputs which formed the basis for separate stakeholder and gap analyses. The outputs of these analyses were then used to develop technical solutions. The feasibility of the approach was tested on a small scale using National GB data for the construction and brick manufacturing industries. Data on exposure intensity were extracted from the National Exposure DataBase (NEDB). Prevalence of exposure was estimated by combining data from the UK census 2011, the Labour Force Survey and a previously established quantitative job exposure matrix. The results were used to illustrate examples of relevant outputs for the system. Overall, these preliminary findings suggest that it is feasible to establish such an intelligence system. This system once developed can provide leading indicators to relevant stakeholders to inform health burden and impact assessments, intervention strategies, and policy actions. A prototype of the system that will be next developed will most likely be based on the example of respirable crystalline silica.