Introduction The Canadian Partnership for Tomorrow’s Health (CanPath) is a multi-centered prospective cohort study, and represents Canada’s largest population health research platform. CanPath holds data and biosamples on more than 330,000 participants from five regional cohorts representing British Columbia, Alberta, Ontario, Quebec, Nova Scotia, New Brunswick, Prince Edward Island, and Newfoundland and Labrador. A sixth cohort representing Manitoba has begun recruitment and Saskatchewan is in the planning stages.

Objectives To examine the genetic, environmental and lifestyle factors that may influence the development of cancer and chronic disease.

Methods A standardized baseline questionnaire was implemented across CanPath between 2009–2015. Participants also provided biosamples including blood, saliva, urine, and toenails, and non-invasive physical measures (height, weight, hip and waist circumference, body composition, and blood pressure). Subsequently, the first follow-up questionnaire was implemented between 2016–2018. Data from supplementary questionnaires are also available from regional cohorts.

Results CanPath holds a harmonized dataset with 1,477 variables including demographics, history of cancer and other chronic disease, lifestyle and health behaviours, and physical measures. Variables of particular relevance to occupational health research include geographic location, sleep, job title, occupational history, work status, and work schedule. In addition, >150,000 participants provided blood and/or other biosamples.

Conclusions CanPath represents a powerful tool for population health research. The survey data and biosamples are available to researchers for future use to gain a more in-depth understanding of the causes and consequences related to occupational health among Canadian residents.