Introduction Epoxy resin systems (ERS) are well-known sensitizers of the skin. A high prevalence of sensitization and dermatitis has been reported among workers exposed to ERS. Due to this, comprehensive personal protective equipment is required when working with ERS. No recent studies have evaluated the effect of the use of such safety equipment.

Objectives The aim of this study was to estimate the occurrence of dermatitis and sensitization to ERS among epoxy-exposed workers producing wind turbine blades in Denmark while using up-to-date protective measures.

Material and Methods A cross-sectional study was performed at two Danish factories producing rotor blades for wind turbines. A screening questionnaire regarding recent and former skin rashes, allergies, atopic dermatitis, and asthma was answered by 181 epoxy-exposed production workers and 41 non-exposed office workers. Physical examination of the skin was followed by testing with a tailored patch test series based on toxicological assessments of possible sensitizing chemicals in the work materials including epoxy resins and hardeners as well as 35 allergens from the European Standard Series (TRUE test). Atopy was defined as elevated serum levels of IgE for standard inhalation allergens.

Results In total, 16 (8.8%) of the exposed workers were sensitized to one or more epoxy compounds, whereas none of the non-exposed office workers were sensitized. Non-atopic participants exposed to epoxy products showed an increased odds ratio (OR=2.02; CI 0.56–7.34) of dermatitis while the opposite was seen for atopic participants (OR=0.08; CI 0.02–0.4). A 4-fold increased odds ratio (OR=4.5; CI 1.57–13.13) of dermatitis was observed among workers sensitized to epoxy resins. Atopy was not associated with epoxy sensitization (OR=0.73, CI 0.22–2.42).

Conclusion Despite up-to date skin protection dermatitis and sensitization to ERS remain high among epoxy exposed lamination workers. These findings document the need for new and efficient preventive efforts.