Introduction Although research on work-family relationship have shown the relevance of balance between these two life domains to explain well-being, the analysis of this effect during COVID-19 lockdown has not yet been examined.

Objectives In this study based on the work-family boundary theory management, we considered that the segmentation from work-to-family had a positive relationship with work-family balanced, which in turn had a positive relationship with flourishing.

Method A sample of 108 teleworkers during the first COVID-19 lockdown (March-April 2020) in Portugal without previous experience with telework answered an on-line questionnaire.

Results The results analyzed with PROCESS (model 4) allowed us to observe that work-to-family segmentation was related with work-family balance and that this work-family balance was the mechanism that explained the positive relationship between work-to-family segmentation and flourishing.

Conclusion Telework is a situation that makes it difficult to establish boundaries between work and family. There must be tools that invest in the development of skills of teleworkers to segment work and family, in order to promote a balance between these domains and, consequently promote teleworkers’ well-being.