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Severe asthma due to occupational exposure to Guar Gum: is Lipid Transfer Protein involved?
  1. Maria Angiola Crivellaro1,
  2. Giacomo Malipiero1,
  3. Pietro Maculan1,
  4. Gianenrico Senna2,
  5. Giovanni Passalacqua3,
  6. Piero Maestrelli4
  1. 1 Department of Cardiac-Thoracic-Vascular Sciences and Public Health, Università degli Studi di Padova, Padova, Italy
  2. 2 Allergologia, Università degli Studi di Verona, Verona, Italy
  3. 3 Dipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, Genova, Italy
  4. 4 Environmental Medicine and Public Health, University of Padova, Padova, Italy
  1. Correspondence to Dr Giacomo Malipiero, Medicina del Lavoro, Padova, Italy; giacomo.malipiero{at}

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Dear Editor, difficult-to-control asthma may be associated with continuous exposure to allergens, particularly professional ones, presence of comorbidities and lack of adherence to therapy. A component-resolved approach can provide an invaluable support to the diagnosis of allergic asthma.1 On the other hand, molecular diagnosis also underlines new questions, as described here.

An otherwise healthy nurse, aged 28 years, experienced onset of asthma symptoms soon after being located to a healthcare facility, hosting patients with disabling neuromuscular diseases. Although a screening skin test, performed at a different Allergy Service, was negative for the common allergenic sources, ImmunoCap (ThermoFisher Scientific, Uppsala, Sweden) revealed the presence of IgE specific to latex and its main allergic component, Hev b 5 …

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  • Contributors All authors contributed equally to the writing and revision of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.