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What characterises work and workplaces that retain their employees following acquired brain injury? Systematic review
  1. Daniele Evelin Alves1,
  2. Wendy Nilsen1,
  3. Silje Christine Reistad Fure2,3,
  4. Heidi Enehaug1,
  5. Emilie Isager Howe4,5,
  6. Marianne Løvstad6,7,
  7. Louisa Fink8,
  8. Nada Andelic4,9,
  9. Øystein Spjelkavik1
  1. 1 Work Research Institute, OsloMet– Oslo Metropolitan University, Oslo, Norway
  2. 2 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
  3. 3 Center for Habilitation and Rehabilitation Models and Services (CHARM), Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway
  4. 4 Department of Physical medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway
  5. 5 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
  6. 6 Department of Psychology, University of Oslo, Oslo, Norway
  7. 7 Department of Research, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway
  8. 8 Institute of Social Psychology, Goethe University Frankfurt, Frankfurt, Hessen, Germany
  9. 9 Center for Habilitation and Rehabilitation Models and Services (CHARM), Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway
  1. Correspondence to Dr Daniele Evelin Alves, Work Research Institute, Oslo Metropolitan University, Oslo, Akershus, Norway; daniele.alves{at}oslomet.no

Abstract

Objectives The objective of this study was to conduct a systematic review assessing workplace factors related to work retention (or return to work) in employees with acquired brain injury (ABI). Additionally, we aimed to synthesise the evidence and state of knowledge on this subject.

Methods A database search was performed in nine relevant electronic databases. Inclusion criteria were quantitative peer-reviewed publications empirically investigating the relationship between work/workplace factors and work retention in employees following ABI. The methodological quality was determined by Effective Public Health Practice Project scoring, and evidence was synthesised narratively.

Results Thirteen studies were included. We found moderate evidence for a negative relationship between manual work and work retention. We also found limited evidence for a U-shaped relationship between workload and complete work retention at 6 months and no relationship at 12 months; a positive relationship between managers, compared with non-managers, and faster work retention; a positive relationship between large enterprise size defined as ≥250 employees, and no relationship between large enterprise size, defined as ≥1000 employees, and work retention.

Conclusion Relative to individual factors, there is little evidence on specific workplace factors’ relationship to work retention among employees with ABI. For most workplace factors, there were too few high-quality studies to designate evidence as more than limited or insufficient. Future studies should replicate rigorous studies of well-defined modifiable workplace factors related to work retention.

PROSPERO registration number CRD42018082201.

  • return to work
  • workplace
  • stroke
  • work retention
  • brain injury
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Key messages

What is already known about this subject?

  • Most single studies and reviews on factors related to return to work for employees with acquired brain injury (ABI) focus on unmodifiable, individual factors such as age, gender and medical characteristics. Although important, individual factors alone cannot translate into guidelines for adaptations at workplaces in order to increase work retention.

What are the new findings?

  • This is the first review to focus and systematically summarise evidence on workplace factors associated with work retention after ABI. The review identified few studies and little sound evidence regarding the specific workplace factors of importance. We found moderate evidence that manual work was negatively associated with work retention, while there was limited and equivocal evidence for the relationship between managerial role, workload and enterprise size, and work retention.

How might this impact on policy or clinical practice in the foreseeable future?

  • Future studies should examine specific modifiable workplace factors by using rigorous designs and well-defined and comparable definitions of work retention. This is necessary to enable the transfer of evidence synthesis into clinical and policy impact. Until then, we suggest that workplaces pay special attention to manual workers after ABI, researchers replicate the strong-quality and moderate-quality studies identified in this review to increase evidence base, and that employers temporarily rely on review findings from other diagnostic groups.

Introduction

Acquired brain injury (ABI) is defined as damage to the brain caused by traumatic or non-traumatic injury.1 Traumatic brain injury (TBI) refers to non-congenital and nondegenerative damage to the brain that is inflicted by an external force. Non - TBI, on the other hand, refers to a range of neurological illnesses (eg, stroke, tumours, brain infections and hypoxia). Although the distinction between TBI and non-TBI is essential for defining early patient management programmes, research suggests that patients suffering from any of the two types of brain injuries report similar challenges when returning back to work. Some of the similar and important barriers are cognitive disabilities, emotional problems and fatigue.1 Further, individuals with ABI tend to shift focus from work to their social networks, struggling to return to a state of normality at the workplace, and perceiving a threat to their competence and work identity. These similarities justify our approach to combine both types of brain injuries when studying work retention, as other studies have done.

Both traumatic and non-traumatic ABI can lead to permanent or temporary disabilities that may limit individuals in their daily activities at home and at work. The prevalence of long-term disability resulting from TBI has been estimated at 3.32 million2 to 5.3 million3 in the USA, and 7.7 million people in the European Union.4 For stroke, the estimated global burden included more than eight million survivors in 2016.5 Hence, ABI imposes a heavy societal burden due to the healthcare and social and vocational support costs, as well as disability pensions involved.6 7

Approximately 70% of patients with ABI are of working age.2 Studies show that both types of ABI negatively affect work retention or return to work (RTW). People with ABI are employed less often, and when employed, they frequently experience difficulties in meeting the physical, cognitive or psychosocial demands of the workplace.8 9 To improve work participation rates after ABI, we need to increase the understanding of what characterises workplaces that retain their employees following ABI.

The complexity of the relationship between brain injury and RTW has been underlined in different reviews.9–12 Shwarz et al 10 pointed out four types of factors predicting RTW: individual, workplace, rehabilitation and their interaction. The authors proposed that a model predicting RTW after stroke should include diverse factors and stakeholders, such as employees, employers, vocational therapists and families.

Most studies investigating work retention after ABI include only individual factors.13–22 Well-established individual factors related to increased work retention are lower injury severity, higher education and male gender. Although undoubtedly important, individual factors alone cannot translate into guidelines for adaptations at workplaces to increase work retention. Compared with individual factors, specific workplace factors are relatively scarce in original studies. Studies that do include workplace factors tend to include them across vast patient populations (all types of injuries),23 in general terms (eg, as one of many overarching factors24 or parts of a complex intervention),8 20 25 26 and lack specificity as to which particular workplace factors are effective. For instance, Donker-Cools et al found strong evidence of the effectiveness of work-directed interventions combined with education or coaching,8 while other general reviews report that interventions were similarly effective.20 25 26 Although informative, reviews including general workplace factors do not identify specific workplace factors associated with work retention. In addition to the skill-advancing programme that aids RTW, there is a need to develop programmes that address the struggles faced by former patients with ABI to retain work. A deeper understanding of the workplace factors that facilitate work retention among former patients with ABI is thus necessary for the development of such programmes. However, to the best of our knowledge, there are no systematic reviews examining the relationship between workplace factors and work retention after ABI. The objective of the current study was thus to fill this gap with a comprehensive systematic review to assess the evidence and state of knowledge regarding workplace factors’ role in work retention after ABI.

Methods

A systematic search using keywords and medical subject heading terms was conducted in February 2018, in the electronic databases Ovid, Web of Science, Scopus, Embase, PsyINFO, SocIndex, Cinahl, Academic search premier, Cochrane Library and Norart. We combined two clusters of keywords and subject headings related to (1) the participants (eg, brain injury, acquired, traumatic and stroke) and (2) the outcome (eg, work/job/employment maintenance, tenure, retention, hours and RTW). This combination of search words enabled any workplace factor (including terminology from other disciplines) to be identified during screening. We collaborated closely with librarians who specialised in systematic reviews and tried out different words and combinations that enabled the identification of as many relevant workplace factors as possible (see appendix 1 for the complete search strategy for each database). At least two reviewers screened the abstracts independently of each other with the online tool Covidence.27 In cases of disagreement, the reviewers discussed until accordance was reached, or a third reviewer was involved. Relevant full texts were retrieved and read.

Supplemental material

This systematic review is registered with International Prospective Register of Systematic Reviews (PROSPERO).28 Guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols checklist29 and the ‘PICO’ approach were used.30 The review team was multidisciplinary and consisted of researchers within the field of occupational psychology, work sociology and neurorehabilitation. In the original protocol, the review included both quantitative and qualitative studies. To improve coherence when synthesising data, we split the original mixed-method review into two manuscripts: one including quantitative studies (the current review) and one including qualitative studies to be published later. Qualitative studies are characterised ‘wrong study design’ in the current review (see figure 1), and deviation from protocol is documented in PROSPERO.

Figure 1

Flow chart of steps in systematic review.

Inclusion and exclusion criteria

Inclusion criteria were peer-reviewed publications quantitatively and empirically investigating the relationship between workplace factors and work retention/RTW in adult employees (ages 18–65 years) in paid employment at the time of ABI. The exposure of interest included all types of workplace factors. Examples of workplace factors were work accommodation, work adaption, flexible work hours, workplace size, interventions involving the workplace, and social support by coworkers and managers. Occupational role was included in the framework of workplace factors because it describes characteristics of the occupation that are related to work retention and can be modified by the workplace to adapt work for employees with brain injury. Individual factors not pertaining to the workplace (eg, personality, age, injury characteristics and medical variables) were excluded from this review. The outcome of interest was work retention (eg, maintenance, tenure and persistent RTW) operationalised in measure of time (eg, days and years) and dichotomous outcomes (eg, work participation 6 months after RTW: yes/no). Studies were included if the relationship between exposure and the outcome variables was tested for statistical significance. There was no publication year limit, as we expected to find few studies investigating the same specific workplace factor and aimed for a wide search. Language was restricted to English, Norwegian, Danish, Swedish, Spanish and Portuguese.

Data extraction

One reviewer extracted data from the included studies, which was double-checked by another reviewer. The data were extracted with a preagreed-upon standardised form covering (1) any workplace factor (‘the exposure factor’) investigated in relationship to the outcome; (2) operationalisation of the work retention and overlapping terms, such as job tenure or RTW (‘the outcome’); (3) quantitative finding of the relationship between the exposure and the outcome; (4) the study characteristics (ie, sample size, study design and response rate); (5) country of origin; and (6) main findings. We grouped studies according to the type of workplace factors investigated in relation to work retention. Studies were then assessed for quality and synthesised for evidence within each workplace factor through a narrative synthesis (see further).

Quality assessment

The Effective Public Health Practice Project (EPHPP, appendix 2) checklist31 was used to assess the quality of the included quantitative studies. Two independent reviewers (authors DEA and SCRF), assessed the quality of each quantitative study into strong, moderate or poor quality. Studies were rated in terms of different components (A–F, see further) and in terms of global ratings. Discrepancies were resolved by discussions or involving a third reviewer (WN). The following six components were evaluated: (A) selection bias, (B) study design, (C) confounders, (D) blinding, (E) data collection methods and (F) withdrawals and drop-outs. A global score was given by transforming each component rating into scores: strong=3, moderate=2, weak=1 or not applicable=0, and summing component ratings, yielding a total score ranging from 5 to 18 for each study. According to its global rating, each study was designated strong (no weak component ratings), moderate (no more than one weak component rating) or weak (more than one weak rating).31

Supplemental material

Evidence synthesis

Finally, we synthesised findings for each specific workplace factors following each study’s EPHPP global rating, and the systematic review evidence synthesis guide (appendix 3).32 The guide’s synthesis algorithm ranges the level of evidence from strong to insufficient.32–34 Evidence is rated strong if three strong studies agree, or if more than three studies, three-fourths of the moderate and strong studies agree. Moderate evidence refers to two strong studies agreeing, or two moderate studies and one strong study agreeing (if more than three studies, more than two-thirds of the moderate and strong studies agree). Limited evidence refers to two moderate and/or strong studies agreeing (if more than two studies, more than one-half of the moderate and strong studies agree). Mixed evidence refers to moderate and strong studies showing contradictory results. Insufficient evidence refers to no strong studies, only one moderate study and/or any number of weak studies.

Supplemental material

Results

The search revealed 5094 records after removing duplicates. After screening abstracts, 202 titles matched the inclusion criteria and were read in full text. Thirteen studies examined statistical associations between workplace factors and work retention after ABI and were included after reading full-text articles35–47 (see figure 1 for the full Preferred Reporting Items for Systematic Reviews and Meta-Analyses flowchart and reasons for exclusion).

Table 1 summarises the study design and operationalisations of workplace factors and work retention in the 13 included studies. All studies were published in English between 1987 and 2017. The majority of the studies used a longitudinal design (n=11); one used a randomised controlled trial (RCT) design (n=1)43; and one cross-sectional design (n=1).36 The duration of follow-up or time since injury varied from 6 months to 7 years. The studies gathered data from nine countries covering four continents: Denmark (n=2),40 41 France (n=2),35 37 Japan (n=2),39 44 Netherlands (n=2),38 45 Great Britain (n=1),42 India (n=1),36 South Africa (n=1),43 Sweden (n=1)46 and the USA (n=1).47

Table 1

Summary of studies included in the systematic analysis*

Sample sizes ranged from 4742 to 19 903.41 The majority of the studies examined stroke (n=7),36 39–41 43 44 46 followed by TBI (n=4),37 38 42 47 while two studies investigated ABI of mixed aetiologies.35 45 Among studies collecting self-report data (n=10),35–38 42–47 only data from employees were collected, while none of the studies included self-reported data from employers or occupational workers/vocational staff. Three studies included national registry data,40 41 47 and nine studies collected data from clinical, occupational or hospital registries.35 37–39 42–46 The included studies examined a total of 16 workplace factors and work retention after ABI (table 2).

Table 2

Workplace factors related to work retention

Two studies assessed work adaptations with onsite assistance (assistance found within the workplace, eg, coworkers, managers and human resources).38 42 Three studies investigated work adaptations with external assistance (ie, assistance from outside the workplace, eg, therapist and employment counselor),37 43 45 while only one study specifically investigated workplace social support.37 The majority of the studies (n=8) were concerned with occupational role,35 36 38 39 41 44 46 47 and two studies investigated enterprise size.39 40

Quality assessment

Most studies (n=8) adjusted for potential confounders and had an acceptable response rate of 60% or more at baseline (n=9). As seen in table 3, only one-third of the studies (n=4) were rated as strong on the global rating of quality (using EPHPP)38–40 47; five studies were rated moderate36 41–43 46; and four studies were rated weak.35 37 44 45

Table 3

Quality assessment of studies based on Effective Public Health Practice Project criteria: total score and quality according to global and component ratings*

Evidence synthesis

In line with the best evidence synthesis guideline, we found that the level of evidence was mostly insufficient, since most specific work factors were only examined in one study (see Evidence synthesis in the Methods section). Only single studies rated as strong are described here since they yield limited evidence on their own (single moderate studies yield insufficient evidence). Studies rated as moderate are only described when they provide evidence in combination with strong studies.

de Koning et al 38 was rated as strong and assessed workload in hours and complete RTW (same number of hours 6 and 12 months after mild TBI). The strong study found that workload in hours per week, which formed a nonlinear U-shaped effect, was predictive for 6-month complete RTW following mild TBI. The curvilinear relationship designates less than 25 work hours a week to the highest odds of complete work retention, 32 hours a week as the lowest odds, followed by increased odds with increased workload. The employees who worked less than 25 hours and more than 32 hours were more likely to fully retain work 6 months after mild TBI. Six months later, workload was not predictive for complete RTW in the same study. According to the systematic review evidence synthesis guide, we found limited evidence that workload was unrelated to complete work retention (in terms of the same number of work hours as preinjury) 1 year after ABI. Six months after ABI, we found limited evidence that workload was related to complete work retention in a U-shaped curve.38

Among eight studies assessing occupational role and work retention, six studies were rated as strong or moderate (equally divided).36 38 39 41 46 47 Although the studies used different definitions of occupational role (see table 2), all categorised manual (or blue-collar) work as having less educational requirements than non-manual (white-collar, skilled or professional) comparisons. Among these studies, four had straightforward findings that manual workers were less likely to RTW than non-manual workers.36 41 46 47 Walker and colleagues’ strong study47 and Hannerz et al’s moderate study41 found higher odds of work retention with increased educational requirements of the job. Two strong studies contained findings pointing in different directions.38 39 De Koning et al’s strong study also found that manual work reduced the probability of full RTW 6 months after mild TBI, compared with skilled work, an effect that was no longer present 1 year after the injury.38 However, professional workers (higher than skilled work in educational requirement) also reduced the probability of full RTW, compared with skilled workers.38 Endo et al’s strong study found that non-manual (desk) workers resigned faster after stroke than manual workers, measured from the first day of sick leave to 1 year after.39 In the same study, another occupational role was investigated: managers returned to work faster than non-managers during the same period. Thus, in the four studies36 41 46 47 (one strong and the remaining moderate) that assessed RTW (as opposed to ‘time to resignation’ or complete RTW), we found moderate evidence that manual work, compared with non-manual work, increased the likelihood of work retention after ABI. We also found limited evidence (one strong study) 39 that managers, compared with non-managers, were more likely to retain work after ABI.

Two strong studies assessed enterprise size and work retention.39 40 However, the studies defined enterprise size so differently that they were evaluated as single studies. One study reported that large enterprise size (≥250 employees) was positively related to RTW 2 years after injury. Each increase in enterprise size (micro, 1–9 employees; small, 10–49 employees; medium, 50–249 employees; and large, ≥250 employees) was followed by an increase in the odds of work retention, 2 years after stroke. In contrast, the other study found that enterprise size (dichotomised as ≤999 employees or ≥1000 employees) was unrelated to RTW 1 year after stroke. Thus, we found limited evidence that large enterprise size defined as ≥250 employees is positively related to work retention, while large enterprise size defined as ≥1000 employees was not related to work retention after ABI.

Discussion

This is the first systematic review to comprehensively screen and synthesise evidence of studies examining specific workplace factors and work retention after ABI. Based on 13 included studies, we found moderate evidence of manual work’s negative relationship with work retention. We also found limited evidence for (1) a U-shaped relationship between workload and complete RTW at 6 months, and no relationship between workload and complete RTW at 12 months; (2) a manager role, compared with a non-manager role; and RTW; (3) large enterprise size (defined as ≥250 employees) as positively related to RTW; and (4) large enterprise size (defined as ≥1000 employees) as unrelated to RTW.

These findings point towards several necessities and some limitations in the field that should be addressed in future studies. First, onsite workplace adaptions are potential avenues for increased RTW. Examples of work adaptations found in our review are a combination of work trials, assistance from coworkers and adapting work hours,42 as well as tailoring workplace interventions according to functional ability and workplace challenges.43 Still, there is a lack of a robust evidence base concerning the association between these modifiable workplace factors and work retention after experiencing ABI. Illustrating this, we found that the relationship between work hours and RTW was complex (U-shaped relation), with both employees working less than 25 and more than 32 hours more likely to fully retain work after 6 months, in one study.38 Because most specific workplace factors were only assessed in one study; more studies with methodological robust study designs are essential to bring this research front forward.

Second, the under-representation found in our review of manual workers among those who retain work after ABI is supported in new single studies,48 49 as well as studies with other patient groups.50 No included studies empirically examined potential mechanisms behind this possible link.51 Lower job control and higher job strain,52 socioeconomic disadvantage,50 premorbid cognitive reserves less conductive to RTW38 53 and the underdetection of physical impairments (eg, balance problems and fine motor skills) after injury54 55 have been suggested as potential pathways from manual work to reduced RTW. Other possible pathways could be insecure work attachment and less work adaptation by employers for manual compared with non-manual workers.

The only specific workplace factors examined in more than one original study in this review were descriptive aspects of workplaces, such as occupational role (eg, manual labour vs non-manual labour) and enterprise size. Although these descriptive factors might be informative, there is a clear need to further examine modifiable aspects of work. Until more strong studies among employees with ABI are conducted and replicated, studies on work retention among other patient groups may be useful in indicating modifiable work factors that might be useful after ABI. Access to multidisciplinary resources11; better assessment of work capacities, clarity on the rights and obligations of employers and workers alike, and the setup of a positive discrimination employment policy51; and job control and (reversed) job strain52 are examples of modifiable workplace factors related to work retention found in other patient groups. Our review is thus a reply to the vocational research community’s former calls for greater focus on the workplace following many types of injury, not only ABI.11 12 15 23 24 51 55 56 Our findings also demonstrate the need to examine mechanisms and processes at the workplace.

Strengths and limitations of the systematic review

The current study used a transparent and comprehensive systematic approach in searching, screening and quality assessing the studies according to predefined criteria with at least two independent reviewers. Also, the standardised EPHPP was used to assess study quality, which has been found to have good inter-rater reliability.34 Still, there are some limitations that should be addressed. The few included studies with heterogeneous samples spanning different cultures, patient groups (ie, in type and severity of ABI) and different operationalisation of exposure and outcome variables warrant caution in generalising the findings. We would particularly like to note that the review contains studies from a diversity of contexts ranging from industrialised (eg, Japan) to low-income countries, thus most probably reflecting different labour practices and protections across study settings. This limits the generalisability of findings.

Although we are confident that we found most peer-reviewed studies after conducting a comprehensive librarian-assisted search in 11 electronic databases, we did not explicitly search for ‘grey literature’ (ie, unpublished studies, such as master or doctoral thesis).57 This poses a risk of publication bias, although grey literature may have little impact on the results.57 Another limitation of the current (and most) review, is that quality assessments are based on the explicit information in the articles and not the actual conduct of the study. This makes it difficult to know the extent of selective reporting (ie, not reporting null findings of some variables).

Implications for practice and research

Our findings suggest that manual workers might be more in need of work adaptation or vocational rehabilitation services after ABI, which is of importance for employers.Efforts should be taken by employers to understand which types of work adaptations or other intervention efforts employees need to be able to retain work. Although current evidence is mostly limited, possible modifiable efforts might be tailoring work tasks, supplying workplace support and adapting work hours. If possible, employers should team up with researchers to conduct more robust scientific evaluations of such efforts to increase the evidence-based knowledge on the field.

The majority of the included studies used longitudinal designs, adjusted for potential confounders, and mostly used valid and reliable instruments. Still, there are several methodological gaps. Some studies had small sample sizes (n<80),35 42 45 thus restricting statistical power and increasing the risk of false-negative findings (ie, ‘type II error’), while others had an unknown response rate (unreported eligible sample).37 42 The majority of the included studies relied on employee data only. Adding a multi-informant perspective, such as employers and vocational support staff, could reduce self-report bias.

In sum, the studies showed large discrepancies in their operationalisation of both the workplace and RTW factor (eg, cut-off in enterprise size).39 Aiming at conducting comparable operationalisation is important for the possibility to compare across studies and lift the evidence base beyond single studies.

Despite the advantages of RCT designs for minimising selection bias and gaining reliable knowledge to be used for policy and practice, only one of the included studies used an RCT design.43 Still, practice-based evidence from large longitudinal cohort studies are also needed to define the effective workplace factors related to RTW and the work retention following ABI,58 and temporal associations can be built on to design interventions that are tested with RCT designs.

Finally, the studies were mostly conducted in high-income countries proposing caution in generalising as national policies, welfare and social security systems vary considerably, also across high-income countries. The findings are also limited by the inability to account for societal factors such as national welfare provisions and labour market forces known to impact RTW following ABI.

Conclusion

It is highly notable that the vast majority of research on work retention after ABI almost solely relies on individual and medical factors,13–22 while we have access to very little sound evidence regarding the specific workplace factors involved.

This is the first systematic review that maps and evaluates evidence of specific workplace factors associated with work retention after ABI. We find moderate evidence that manual work is associated with lower work retention, but a need to go further and examine potential mechanisms thereof. There is a need to conduct methodologically robust studies of workplace interventions focusing on modifiable workplace factors to increase RTW among employees with ABI. Compared with the quite extensive literature regarding individual and medical factors, only one RCT regarding workplace variables was identified in this review. This demonstrates that the field of workplace adaptations after ABI is still a long way from taking into account the full complexity of factors that contribute to increasing or decreasing the chance of individuals retaining work after ABI. Also, clinical practice should take into account not only that individual and injury-related factors are at play but also that many aspects related to the workplace will be important to address when helping patients return to their previous workplace.

Acknowledgments

We thank Vilde Hoff Bernstrøm, who helped with the study design and screening; Pål Klethagen, who helped with the screening; Katrine Ziesler, who helped with the figure; and Bettina Grødem Knutsen, Malene Wølch Gundersen and Ingjerd Legreid Ødemark, who helped with the systematic literature search.

References

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Footnotes

  • Twitter @wendy_nilsen

  • Collaborators Vilde Hoff Bernstrøm, Pål Klethagen, Bettina Grødem Knutsen, Malene Wølch Gundersen and Ingjerd Legreid Ødemark.

  • Contributors Study concept and design: DEA, WN, VHB, ØS, HE, NA and ML. Screening: DEA, ØS, LF, PK, HE, NA, EIH, ML and VHB. Quality assessment: DEA, SCRF, WN, EIH, LF, NA, ML, HE and ØS. Literature search: BGK, MWG and ILO. Evidence synthesis: DEA, WN and ML. Funding applications: NA, ØS, HE and ML. Drafting of the manuscript: DEA, WN, EIH, SCRF, NA, ML, HE, ØSand LF. Critical revision of the manuscript for important intellectual content: all authors. DEA: guarantor.

  • Funding This research was partly funded by the Research Council of Norway (grant 256 689); the Work Research Institute, OsloMet–Oslo Metropolitan University; and the Department of Research, Sunnaas Rehabilitation Hospital.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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