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  • Maternal occupational exposure to solvents and gastroschisis in offspring: are gene–environment interactions playing a role?

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Maternal occupational exposure to solvents and gastroschisis in offspring: are gene–environment interactions playing a role?
  1. Qing Chang1,
  2. Hong-Lin Chen2
  1. 1 Wuxi No.8 People's Hospital and Wuxi Occupational Disease Hospital, Wuxi, Jiangsu Province, China
  2. 2 School of Public Health, Nantong University, Nantong, Jiangsu Province, China
  1. Correspondence to Dr Qing Chang, Wuxi No.8 People's Hospital and Wuxi Occupational Disease Hospital, Wuxi City, Jiangsu Province, China; q_chang{at}sohu.com

https://doi.org/10.1136/oemed-2020-106627

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    In a recent issue of Occupational and Environmental Medicine, a study by Spinder et al 1 reported the results of the association between maternal occupational exposure to solvents and gastroschisis in offspring. Spinder et al found that among 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively, and exposure to solvent versus no exposure was not associated with gastroschisis after adjusting for maternal age (OR 1.00, 95% CI 0.75 to 1.32), nor was an association noted for solvent classes.1 However, we think this conclusion should be treated with caution.

    Gene–environment …

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    Footnotes

    • Contributors Both authors contributed equally.

    • Funding This research received a grant from Wuxi City Key Clinical Specialty (Occupational Disease) Construction Plan.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; internally peer reviewed.